[HTML][HTML] Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models
MA Heinrich, AMRH Mostafa, JP Morton… - Advanced drug delivery …, 2021 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
Pancreatic Ductal Adenocarcinoma: Preclinical in vitro and ex vivo Models
B Gündel, X Liu, M Löhr, R Heuchel - Frontiers in cell and …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is one of the most overlooked cancers despite its
dismal median survival time of 6 months. The biggest challenges in improving patient …
dismal median survival time of 6 months. The biggest challenges in improving patient …
Pancreatic cancer microenvironment and cellular composition: current understandings and therapeutic approaches
LH Truong, S Pauklin - Cancers, 2021 - mdpi.com
Simple Summary There is currently no effective treatment for Pancreatic Ductal
Adenocarcinoma (PDAC), and it is still the deadliest cancer, despite great research efforts in …
Adenocarcinoma (PDAC), and it is still the deadliest cancer, despite great research efforts in …
A Novel Scaffold-Based Hybrid Multicellular Model for Pancreatic Ductal Adenocarcinoma—Toward a Better Mimicry of the in vivo Tumor Microenvironment
With a very low survival rate, pancreatic ductal adenocarcinoma (PDAC) is a deadly
disease. This has been primarily attributed to (i) its late diagnosis and (ii) its high resistance …
disease. This has been primarily attributed to (i) its late diagnosis and (ii) its high resistance …
Ex vivo culture of intact human patient derived pancreatic tumour tissue
The poor prognosis of pancreatic ductal adenocarcinoma (PDAC) is attributed to the highly
fibrotic stroma and complex multi-cellular microenvironment that is difficult to fully …
fibrotic stroma and complex multi-cellular microenvironment that is difficult to fully …
The tumour microenvironment in pancreatic cancer—clinical challenges and opportunities
WJ Ho, EM Jaffee, L Zheng - Nature reviews Clinical oncology, 2020 - nature.com
Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …
A biomimetic tumor model of heterogeneous invasion in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a complex, heterogeneous, and genetically
unstable disease. Its tumor microenvironment (TME) is complicated by heterogeneous …
unstable disease. Its tumor microenvironment (TME) is complicated by heterogeneous …
[HTML][HTML] 3D approaches to model the tumor microenvironment of pancreatic cancer
In tumor engineering, 3D approaches are used to model components of the tumor
microenvironment and to test new treatments. Pancreatic cancers are a cancer of substantial …
microenvironment and to test new treatments. Pancreatic cancers are a cancer of substantial …
Patient-derived xenograft models of pancreatic cancer: overview and comparison with other types of models
PL Garcia, AL Miller, KJ Yoon - Cancers, 2020 - mdpi.com
Pancreatic cancer (PC) is anticipated to be second only to lung cancer as the leading cause
of cancer-related deaths in the United States by 2030. Surgery remains the only potentially …
of cancer-related deaths in the United States by 2030. Surgery remains the only potentially …
Modeling pancreatic cancer in mice for experimental therapeutics
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …