Sox4 expression is restricted in mammals to embryonic structures and some adult tissues,
such as lymphoid organs, pancreas, intestine, and skin. During embryogenesis, Sox4 …

The transcription factor Sox2 maintains the pluripotency of early embryonic cells and
regulates the formation of several epithelia during fetal development. Whether Sox2 …

Background Quiescent tumor cells pose a major clinical challenge due to their ability to
resist conventional chemotherapies and to drive tumor recurrence. Understanding the …

SOX2 (Sex-determining region Y box 2) is a transcription factor expressed in several foetal
and adult tissues and its deregulated activity has been linked to chronic diseases associated …

Sox2 is well known for its functions in embryonic stem (ES) cell pluripotency, maintenance,
and self-renewal, and it is an essential factor in generating inducible pluripotent stem (iPS) …

Sox2 is a key transcription factor required for the maintenance of pluripotency in embryonic
cells and morphogenesis of several epithelia. In this issue of Cell Stem Cell, Arnold et …

SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …

In this study, we investigated the expression and putative role of Sox9 in epidermal
keratinocyte. Immunohistochemical staining showed that Sox9 is predominantly expressed …

The developmental regulator SOX9 is linked to cancer progression mainly as a result of its
role in the regulation of cancer stem cells (CSCs). However, its activity in the differentiated …

The Sry-containing protein Sox2 initially was known to regulate the self-renewal of the
mouse and human embryonic stem cells (ESCs). It is also important for the maintenance of …