Sleep is homeostatically regulated with sleep pressure accumulating with the increasing
duration of prior wakefulness. Yet, a clear understanding of the molecular components of the …

Sleep is critical for diverse aspects of brain function in animals ranging from invertebrates to
humans. Powerful genetic tools in the fruit fly Drosophila melanogaster have identified—at …

It has been known for a long time that genetic factors affect sleep quantity and quality.
Genetic screens have identified several mutations that affect sleep across species, pointing …

Abstract Study Objectives: The fruit fly Drosophila melanogaster is emerging as a promising
model system for the genetic dissection of sleep. As in mammals, sleep in the fruit fly is a …

The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

In 2000, Drosophila melanogaster joined the ranks of vertebrates and invertebrates with a
defined behavioral sleep state. The characterization of this sleep state revealed striking …

Sleep is thought to be controlled by two main processes: a circadian clock that primarily
regulates sleep timing and a homeostatic mechanism that detects and responds to sleep …

Molecular and genetic approaches in several species have provided new insights into the
mechanisms of rest-activity and sleep-wake regulation. Many of these discoveries are …

Sleep is present and tightly regulated in every vertebrate species in which it has been
carefully investigated, but what sleep is for remains a mystery. Sleep is also present in …

Highlights•Complex regulation of sleep and wake is traced through mushroom body input
and outputs.•The central complex promotes sleep and mediates sleep-drive.• …