Noninvasive methods to modulate G protein-coupled receptors (GPCRs) with temporal and
spatial precision are in great demand. Photopharmacology uses photons to control in situ …

Spatiotemporal control over biochemical signaling processes involving G protein‐coupled
receptors (GPCRs) is highly desired for dissecting their complex intracellular signaling. We …

G protein-coupled receptors (GPCRs) are the most common targets of drug discovery.
However, the similarity between related GPCRs combined with the complex spatiotemporal …

Serotonin receptors play central roles in neuromodulation and are critical drug targets for
psychiatric disorders. Optical control of serotonin receptor subtypes has the potential to …

Red-shifted azobenzene scaffolds have emerged as useful molecular photoswitches to
expand potential applications of photopharmacological tool compounds. As one of them …

Despite the power of photopharmacology for interrogating signaling proteins, many
photopharmacological systems are limited by their efficiency, speed, or spectral properties …

Photo‐controlled affinity reagents seek to provide modular spatiotemporal control of
bioactivity by conferring photo‐switchability of function on an affinity reagent scaffold. Herein …

Azobenzene-embedded photoswitchable ligands are the widely used chemical tools in
photopharmacological studies. Current approaches to azobenzene introduction rely mainly …

The limitations of classical drugs have spurred the development of covalently tethered
photoswitchable ligands to control neuromodulatory receptors. However, a major …

G protein-coupled receptors (GPCR), including the metabotrobic glutamate 5 receptor
(mGlu5), are important therapeutic targets and the development of allosteric ligands for …