This experimental study was designed to evaluate the effect of ulinastatin, a urinary trypsin
inhibitor, on postoperative cognitive dysfunction (POCD) in rats under general anesthesia …

Objective: Postoperative neurocognitive disease (PNCD) in the aged is a major clinical
problem with unclear mechanisms. This study was designed to explore the mechanisms for …

Postoperative cognitive dysfunction (POCD) is very common complication of surgery in aged
individuals. Accumulated evidence suggests that neuroinflammation may be the underlying …

Background: Perioperative neurocognitive disorders (PND) occur frequently and refer to
alterations in cognitive function after surgery, especially in elderly patients. PND is …

Ulinastatin [or called as urinary trypsin inhibitor (UTI)] plays a role in regulating neurological
deficits evoked by transient cerebral ischemia. However, the underlying mechanisms still …

Background: Recent studies have shown that early diagnosis and intervention promote the
patient's good prognosis. For patients who underwent cardiac surgery and require …

PURPOSE: Ulinastatin, a urinary trypsin inhibitor, is widely used to treat acute systemic
inflammatory disorders. However, its effects on early postoperative cognitive function have …

Objective To evaluate the effect of icariin on sevoflurane-induced postoperative cognitive
dysfunction (POCD), and to explore its potential mechanism. Methods The mice were …

Tissue-type plasminogen activator (t-PA) and matrix metalloproteinase-9 (MMP-9) have
been reported to play important roles in increased permeability of blood–brain barrier (BBB) …

Ulinastatin [also called urinary trypsin inhibitor (UTI)] has beneficial effects on cerebral
ischemic injury evoked by cardiac arrest (CA). However, the underlying mechanisms are …