Cholinergic white matter pathways in dementia with Lewy bodies and Alzheimer's disease

J Schumacher, NJ Ray, CA Hamilton, PC Donaghy… - Brain, 2022 - academic.oup.com
Patients who have dementia with Lewy bodies and Alzheimer's disease show early
degeneration of the cholinergic nucleus basalis of Meynert. However, how white matter …

Cholinergic white matter pathways along the Alzheimer's disease continuum

M Nemy, M Dyrba, F Brosseron, K Buerger, P Dechent… - Brain, 2023 - academic.oup.com
Previous studies have shown that the cholinergic nucleus basalis of Meynert and its white
matter projections are affected in Alzheimer's disease dementia and mild cognitive …

Free water imaging of the cholinergic system in dementia with Lewy bodies and Alzheimer's disease

J Schumacher, NJ Ray, CA Hamilton… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Degeneration of cortical cholinergic projections from the nucleus basalis of
Meynert (NBM) is characteristic of dementia with Lewy bodies (DLB) and Alzheimer's …

Severe cholinergic terminal loss in newly diagnosed dementia with Lewy bodies

N Okkels, J Horsager, M Labrador-Espinosa… - Brain, 2023 - academic.oup.com
Cholinergic changes play a fundamental role in the natural history of dementia with Lewy
bodies and Lewy body disease in general. Despite important achievements in the field of …

[HTML][HTML] In vivo nucleus basalis of Meynert degeneration in mild cognitive impairment with Lewy bodies

J Schumacher, JP Taylor, CA Hamilton, M Firbank… - NeuroImage: Clinical, 2021 - Elsevier
Objectives To investigate in vivo degeneration of the cholinergic system in mild cognitive
impairment with Lewy bodies (MCI-LB), we studied nucleus basalis of Meynert (NBM) …

Structural (dys) connectivity associates with cholinergic cell density in Alzheimer's disease

CP Lin, I Frigerio, BDC Boon, Z Zhou, AJM Rozemuller… - Brain, 2022 - academic.oup.com
Cognitive deficits in Alzheimer's disease, specifically amnestic (memory dominant) deficits,
are associated with cholinergic degeneration in the basal forebrain. The cholinergic nucleus …

Longitudinal atrophy in prodromal dementia with Lewy bodies points to cholinergic degeneration

K Kantarci, Z Nedelska, Q Chen, ML Senjem… - Brain …, 2022 - academic.oup.com
Mild cognitive impairment with the core clinical features of dementia with Lewy bodies is
recognized as a prodromal stage of dementia with Lewy bodies. Although grey matter …

[HTML][HTML] Cholinergic white matter pathways make a stronger contribution to attention and memory in normal aging than cerebrovascular health and nucleus basalis of …

M Nemy, N Cedres, MJ Grothe, JS Muehlboeck… - Neuroimage, 2020 - Elsevier
The integrity of the cholinergic system plays a central role in cognitive decline both in normal
aging and neurological disorders including Alzheimer's disease and vascular cognitive …

Subcortical whiter matter hyperintensities within the cholinergic pathways of patients with dementia and parkinsonism

HE Park, IS Park, YS Oh, DW Yang, KS Lee… - Journal of the …, 2015 - Elsevier
Background and purpose White matter hyperintensities (WMHs) in the cholinergic pathways
are associated with cognitive performance in Alzheimer's disease (AD) and Parkinson …

[HTML][HTML] Frontal and periventricular brain white matter lesions and cortical deafferentation of cholinergic and other neuromodulatory axonal projections

NI Bohnen, CW Bogan, M Müller - European neurological journal, 2009 - ncbi.nlm.nih.gov
White matter fiber bundles form a spatial pattern defined by anatomical and functional
architecture. Structural lesions in the white matter may cause clinical symptoms because of …