We describe here the identification and functional characterization of the enzyme O-
GlcNAcase (OGA) as an RNA polymerase II elongation factor. Using in vitro transcription …

Most human genes are loaded with promoter-proximally paused RNA polymerase II (Pol II)
molecules that are poised for release into productive elongation by P-TEFb. We present …

Gdown1, the substoichiometric 13th subunit of RNA polymerase II (pol II), has an important
role in pausing during the initial stage of transcript elongation. However, Gdown1 …

Pausing during the earliest stage of transcript elongation by RNA polymerase II (Pol II) is a
nearly universal control point in metazoan gene expression. The substoichiometric Pol II …

Although the O-linked N-acetylglucosamine (O-GlcNAc) modification of the RNA polymerase
II C-terminal domain was described 20 years ago, the function of this RNA polymerase II (pol …

Spt5 is a highly conserved RNA polymerase II (Pol II)‐associated pausing and elongation
factor. However, its impact on global elongation and Pol II processivity in mammalian cells …

Promoter-proximal pausing by RNA polymerase II (Pol II) ensures gene-specific regulation
and RNA quality control. Structural considerations suggested a requirement for initiation …

Over the past few years, biochemical and genetic studies have shed considerable light on
the structure and function of the RNA polymerase II (pol II) elongation complex and the …

During its journey across a gene, RNA polymerase II has to contend with a number of
obstacles to its progression, including nucleosomes, DNA-binding proteins, DNA damage …

Over the past year, key advances in several areas of research on the structure and function
of the RNA polymerase (pol II) elongation complex have shed considerable light on the …