O-GlcNAcase is an RNA polymerase II elongation factor coupled to pausing factors SPT5 and TIF1β
M Resto, BH Kim, AG Fernandez, BJ Abraham… - Journal of Biological …, 2016 - ASBMB
We describe here the identification and functional characterization of the enzyme O-
GlcNAcase (OGA) as an RNA polymerase II elongation factor. Using in vitro transcription …
GlcNAcase (OGA) as an RNA polymerase II elongation factor. Using in vitro transcription …
Functional association of Gdown1 with RNA polymerase II poised on human genes
B Cheng, T Li, PB Rahl, TE Adamson, NB Loudas… - Molecular cell, 2012 - cell.com
Most human genes are loaded with promoter-proximally paused RNA polymerase II (Pol II)
molecules that are poised for release into productive elongation by P-TEFb. We present …
molecules that are poised for release into productive elongation by P-TEFb. We present …
Functional interactions of the RNA polymerase II-interacting proteins Gdown1 and TFIIF
Gdown1, the substoichiometric 13th subunit of RNA polymerase II (pol II), has an important
role in pausing during the initial stage of transcript elongation. However, Gdown1 …
role in pausing during the initial stage of transcript elongation. However, Gdown1 …
Gdown1 associates efficiently with RNA polymerase II after promoter clearance and displaces TFIIF during transcript elongation
E DeLaney, DS Luse - PLoS One, 2016 - journals.plos.org
Pausing during the earliest stage of transcript elongation by RNA polymerase II (Pol II) is a
nearly universal control point in metazoan gene expression. The substoichiometric Pol II …
nearly universal control point in metazoan gene expression. The substoichiometric Pol II …
Human RNA polymerase II promoter recruitment in vitro is regulated by O-linked N-acetylglucosaminyltransferase (OGT)
Although the O-linked N-acetylglucosamine (O-GlcNAc) modification of the RNA polymerase
II C-terminal domain was described 20 years ago, the function of this RNA polymerase II (pol …
II C-terminal domain was described 20 years ago, the function of this RNA polymerase II (pol …
Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation
Spt5 is a highly conserved RNA polymerase II (Pol II)‐associated pausing and elongation
factor. However, its impact on global elongation and Pol II processivity in mammalian cells …
factor. However, its impact on global elongation and Pol II processivity in mammalian cells …
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
S Larochelle, R Amat, K Glover-Cutter… - Nature structural & …, 2012 - nature.com
Promoter-proximal pausing by RNA polymerase II (Pol II) ensures gene-specific regulation
and RNA quality control. Structural considerations suggested a requirement for initiation …
and RNA quality control. Structural considerations suggested a requirement for initiation …
Mechanism and regulation of transcriptional elongation by RNA polymerase II
D Reines, RC Conaway, JW Conaway - Current opinion in cell biology, 1999 - Elsevier
Over the past few years, biochemical and genetic studies have shed considerable light on
the structure and function of the RNA polymerase II (pol II) elongation complex and the …
the structure and function of the RNA polymerase II (pol II) elongation complex and the …
Ubiquitylation and degradation of elongating RNA polymerase II: the last resort
MD Wilson, M Harreman, JQ Svejstrup - Biochimica et biophysica acta (bba …, 2013 - Elsevier
During its journey across a gene, RNA polymerase II has to contend with a number of
obstacles to its progression, including nucleosomes, DNA-binding proteins, DNA damage …
obstacles to its progression, including nucleosomes, DNA-binding proteins, DNA damage …
Mechanism and regulation of transcriptional elongation and termination by RNA polymerase II
A Shilatifard, JW Conaway, RC Conaway - Current opinion in genetics & …, 1997 - Elsevier
Over the past year, key advances in several areas of research on the structure and function
of the RNA polymerase (pol II) elongation complex have shed considerable light on the …
of the RNA polymerase (pol II) elongation complex have shed considerable light on the …
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- rna polymerase transcriptional elongation
- rna polymerase functional association
- rna polymerase human genes
- rna polymerase last resort
- rna polymerase kinase control
- rna polymerase promoter clearance
- rna polymerase ubiquitylation and degradation
- rna polymerase transcript elongation
- rna polymerase functional interactions