Background: Fusion transcripts are formed by either fusion genes (DNA level) or trans-
splicing events (RNA level). They have been recognized as a promising tool for diagnosing …

RNA-Seq made possible the global identification of fusion transcripts, ie “chimeric RNAs”.
Even though various software packages have been developed to serve this purpose, they …

Background Fusion genes are known to be drivers of many common cancers, so they are
potential markers for diagnosis, prognosis or therapy response. The advent of paired-end …

Analysis of fusion transcripts has become increasingly important due to their link with cancer
development. Since high-throughput sequencing approaches survey fusion events …

Background. Gene fusions arising from chromosomal translocations have been implicated in
cancer. RNA‐seq has the potential to discover such rearrangements generating functional …

Motivation: Fusion transcripts can be created as a result of genome rearrangement in
cancer. Some of them play important roles in carcinogenesis, and can serve as diagnostic …

Background Accurate fusion transcript detection is essential for comprehensive
characterization of cancer transcriptomes. Over the last decade, multiple bioinformatic tools …

We have developed a new method, SOAPfuse, to identify fusion transcripts from paired-end
RNA-Seq data. SOAPfuse applies an improved partial exhaustion algorithm to construct a …

Motivation: Next generation sequencing technology generates high-throughput data, which
allows us to detect fusion genes at both transcript and genomic levels. To detect fusion …

Motivation: Paired-end whole transcriptome sequencing provides evidence for fusion
transcripts. However, due to the repetitiveness of the transcriptome, many reads have …