Simple Summary The mitogen-activated protein kinase/extracellular signal-regulated kinase
(MAPK/ERK) signaling pathway is frequently activated in liver cancer, which is one of the …

Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide and has a very
poor prognosis. Its occurrence has been on the increase in recent years. Surgical resection …

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK)
is a key molecule in intracellular signal transducing pathways that transport extracellular …

Although the biological basis of hepatocellular carcinoma (HCC) remains unclear, effective
treatments and improvement of the survival rate remain worthwhile research goals …

Hepatocellular carcinoma (HCC) is among the most frequently occurring cancers and the
leading causes of cancer mortality worldwide. Identification of the signaling pathways …

Background Human hepatocellular carcinoma (HCC) is associated with increased
expression and activity of mitogen-activated protein kinase (MAPK) signaling intermediates …

Background Hepatocellular carcinoma (HCC) is still a major health problem, often
diagnosed at an advanced stage. The multikinase inhibitor sorafenib is to date the sole …

Background Hepatocellular carcinoma (HCC) is one of the most common malignancies in
South East Asia. Although activation of the MEK-MAPK is often associated with cellular …

Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …

Mitogen-activated protein kinase (MAPK) cascades are key signaling pathways involved in
the regulation of normal cell proliferation, survival and differentiation. Aberrant regulation of …