Epithelial–mesenchymal transition: a new target in anticancer drug discovery

F Marcucci, G Stassi, R De Maria - Nature reviews Drug discovery, 2016 - nature.com
The conversion of cells with an epithelial phenotype into cells with a mesenchymal
phenotype, referred to as epithelial–mesenchymal transition, is a critical process for …

[HTML][HTML] Epithelial-mesenchymal transition in cancer: a historical overview

D Ribatti, R Tamma, T Annese - Translational oncology, 2020 - Elsevier
Abstract Epithelial-mesenchymal transitions (EMTs), the acquisition of mesenchymal
features from epithelial cells, occur during some biological processes and are classified into …

Epithelial-mesenchymal transition (EMT) as a therapeutic target

S Jonckheere, J Adams, D De Groote… - Cells Tissues …, 2022 - karger.com
Metastasis is the spread of cancer cells from the primary tumour to distant sites and organs
throughout the body. It is the primary cause of cancer morbidity and mortality, and is …

[HTML][HTML] Novel clinical therapeutics targeting the epithelial to mesenchymal transition

AN Kothari, Z Mi, M Zapf, PC Kuo - Clinical and translational medicine, 2014 - Springer
The epithelial to mesenchymal transition (EMT) is implicated in many processes, ranging
from tissue and organogenesis to cancer and metastatic spread. Understanding the key …

Epithelial-mesenchymal transition: implications in cancer progression and metastasis

LR Gomes, LF Terra, MC Sogayar… - Current …, 2011 - ingentaconnect.com
During the past few years, Epithelial-Mesenchymal Transition (EMT) has emerged as one of
the most hot spots in clinical research. Its existence in human tumors can form the basis for …

Epithelial to mesenchymal transition in a clinical perspective

J Pasquier, N Abu-Kaoud, H Al Thani… - Journal of …, 2015 - Wiley Online Library
Tumor growth and metastatic dissemination rely on cellular plasticity. Among the different
phenotypes acquired by cancer cells, epithelial to mesenchymal transition (EMT) has been …

[HTML][HTML] Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Y Zhang, RA Weinberg - Frontiers of medicine, 2018 - Springer
The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an
important role in both development and cancer progression. Depending on the contextual …

Induction and regulation of epithelial–mesenchymal transitions

B Boyer, AM Vallés, N Edme - Biochemical pharmacology, 2000 - Elsevier
Herein we discuss the factors that bring about the transformation of epithelial cells into cells
of fibroblastic phenotype. This type of transformation, referred to as epithelium-to …

Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

[HTML][HTML] A cell-based small molecule screening method for identifying inhibitors of epithelial-mesenchymal transition in carcinoma

KN Chua, WJ Sim, V Racine, SY Lee, BC Goh… - PloS one, 2012 - journals.plos.org
Epithelial Mesenchymal Transition (EMT) is a crucial mechanism for carcinoma progression,
as it provides routes for in situ carcinoma cells to dissociate and become motile, leading to …