Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central
nervous system, ranging from the regulation of gene transcription, cellular signaling …

Glucocorticoids, the adrenal steroids secreted during stress, while critical for successful
adaptation to acute physical stressors, can have a variety of deleterious effects if secreted in …

Stress is a risk factor for a variety of illnesses, involving the same hormones that ensure
survival during a period of stress. Although there is a considerable ambiguity in the definition …

Stress, injury, and disease trigger glucocorticoid (GC) elevation. Elevated GCs bind to the
ubiquitously expressed glucocorticoid receptor (GR). While GRs are in every cell in the …

The hippocampal formation expresses high levels of adrenal steroid receptors and is a
malleable brain structure that is important for certain types of learning and memory. It is also …

Exposure to stressful situations activates two hormonal systems that help the organism to
adapt. On the one hand stress hormones achieve adaptation by affecting peripheral organs …

Increasingly, stress is recognized as a trigger of depressive episodes and recent evidence
suggests a causal role of stress in the onset and progression of Alzheimer's disease (AD) …

An extensive literature demonstrates that glucocorticoids (GCs), the adrenal steroids
secreted during stress, can have a broad range of deleterious effects in the brain. The …

One of the conundrums in today's stress research is why some individuals flourish and
others perish under similar stressful conditions. It is recognized that this individual variability …

Over the last 50 years, the concept of stress has evolved significantly, and our
understanding of the underlying neurobiology has expanded dramatically. Rather than …