The Alzheimer's disease-associated peptide amyloid-beta (Aβ) has been associated with
neuronal hyperactivity under anesthesia, but clinical trials of anticonvulsants or neural …

Transgenic mice are used to model increased brain amyloid-β (Aβ) and amyloid plaque
formation reflecting Alzheimer's disease pathology. In our study hippocampal network …

Accumulation of amyloid plaques comprises one of the major hallmarks of Alzheimer's
disease (AD). In rodents, acute treatment with amyloid-beta (Aβ; 1–42) elicits immediate …

Dysregulated homeostasis of neural activity has been hypothesized to drive Alzheimer's
disease (AD) pathogenesis. AD begins with a decades-long presymptomatic phase, but …

In recent years, aberrant neural oscillations in various cortical areas have emerged as a
common physiological hallmark across mouse models of amyloid pathology and patients …

Neural network dysfunction may play an important role in Alzheimer's disease (AD).
Neuronal circuits vulnerable to AD are also affected in human amyloid precursor protein …

Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural
excitation and inhibition, is found in patients with mild cognitive impairment, a prodromal …

Occurrence of amyloid-β (Aβ) aggregation in brain begins before the clinical onset of
Alzheimer's disease (AD), as preclinical AD. Studies have reported that sleep problems and …

The mechanisms that confer cognitive resilience to Alzheimer's Disease (AD) are not fully
understood. Here, we describe a neural circuit mechanism underlying this resilience in a …

Alzheimer's disease (AD) progresses with a deterioration of hippocampal function that is
likely induced by amyloid beta (Aβ) oligomers. Hippocampal function is strongly dependent …