Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors,
including feeding, but less is known about how these circuits may interact. In this study, we …

Dopamine (DA) signal play pivotal roles in regulating motivated behaviors, including feeding
behavior, but the role of midbrain DA neurons in modulating food intake and neural circuitry …

Background Neural networks that regulate binge eating remain to be identified, and effective
treatments for binge eating are limited. Methods We combined neuroanatomic …

Obesity is primarily a consequence of consuming calories beyond energetic requirements,
but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons …

Anorexia nervosa (AN) is an eating disorder observed predominantly in women and girls
that is characterized by a low body-mass index, hypophagia, and hyperactivity. Activity …

Objective Serotonin (5HT) is a well-known anorexigenic molecule, and 5HT neurons of
dorsal raphe nucleus (DRN) have been implicated in suppression of feeding; however, the …

Background: Dopamine (DA) signalling in the brain is necessary for feeding behaviour, and
alterations in the DA system have been linked to obesity. However, the precise role of DA in …

Feeding satisfies metabolic need but is also controlled by external stimuli, like palatability or
predator threat. Nucleus accumbens shell (NAcSh) projections to the lateral hypothalamus …

We found that development of obesity was coupled with emergence of a progressively
worsening deficit in neural reward responses. Similar changes in reward homeostasis …

Overeating typically follows periods of energy deficit, but it is also sustained by highly
palatable foods, even without metabolic demand. Dopamine D1 receptor-expressing …