Background Folate and its synthetic form folic acid function as donor of one-carbon units and
have been, together with other B-vitamins, implicated in programming of epigenetic …

Background Changes in DNA methylation, one of the most studied epigenetic mechanisms,
are considered an initial marker for early cancer detection. We evaluated how availability of …

Significance: The progressive, dose-dependent, and potentially reversible epigenetic
changes observed in cancer present new opportunities in cancer risk modification and …

DNA methylation is one of several epigenetic mechanisms that play a regulatory role in
genome programming and imprinting during embryogenesis. Aberrant DNA methylation has …

Background Folate and vitamin B-12 are essential micronutrients involved in the donation of
methyl groups in cellular metabolism. However, associations between intake of these …

Scope Alterations in DNA methylation patterns are correlated with aging, environmental
exposures, and disease pathophysiology; the possibility of reverting or preventing these …

Epigenetics (particularly DNA methylation) together with environmental and genetic factors,
are key to understanding the pathogenesis of many diseases including dementia …

Experimental studies demonstrated that maternal exposure to certain environmental and
dietary factors during early embryonic development can influence the phenotype of offspring …

DNA methylation is an epigenetic mechanism that regulates gene expression and can be
modified by one-carbon nutrients. The objective of this study was to investigate the impact of …

Folate is a source of one-carbons necessary for DNA methylation, a critical epigenetic
modification necessary for genomic structure and function. The use of supplemental folic …