Ketamine is a novel drug used for treatment-resistant depression. KETAMINE RESPONSE
AND BIPOLAR DISORDER SUBTYPE This study raises an important question-does …

Objectives Ketamine has shown rapid antidepressant effects in depressed patients.
However, the antidepressant and antisuicidal effects of repeated ketamine infusions in …

Purpose Bipolar disorder is a chronic and recurrent condition often associated with
treatment resistance and suicidality. There is an unmet need for effective treatment in this …

BACKGROUND: Currently, no pharmacological treatments for bipolar depression exist that
exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that …

The most recent data from the Global Burden of Disease Study highlight that 47.5%(ie, 183.9
million) of all disability-adjusted life years are attributable to mood disorders with an …

Bipolar disorder (BD) is a recurrent condition with fluctuating mood swings from energetic
mania/hypomania to severe depression, leading to significant disability and a high risk of …

Currently available drugs for unipolar major depressive disorder (MDD), which target
monoaminergic systems, have a delayed onset of action andsignificant limitations in …

Dear Dr. Price, We read with great interest the letter of McGuirr and Berlim (2014) in
response to our work. We are in agreement with their general comment on improving …

Since the first report of a robust antidepressant effect of a sub-anesthetic dose of ketamine in
2000, studies have repeatedly confirmed its therapeutic benefits in major depressive …

Objective: To study the clinical effect of a single ketamine infusion, 0.5 mg/kg body weight, in
bipolar depressive patients receiving mood-stabilising drugs, not improving on …