CRF antagonism within the ventral tegmental area but not the extended amygdala attenuates the anxiogenic effects of cocaine in rats
A Ettenberg, SW Cotten, MA Brito, AK Klein… - Pharmacology …, 2015 - Elsevier
In addition to its initial rewarding effects, cocaine has been shown to produce profound
negative/anxiogenic actions. Recent work on the anxiogenic effects of cocaine has …
negative/anxiogenic actions. Recent work on the anxiogenic effects of cocaine has …
Noradrenergic β-receptor antagonism within the central nucleus of the amygdala or bed nucleus of the stria terminalis attenuates the negative/anxiogenic effects of …
JM Wenzel, SW Cotten, HM Dominguez… - Journal of …, 2014 - Soc Neuroscience
Cocaine has been shown to produce both initial rewarding and delayed anxiogenic effects.
Although the neurobiology of cocaine's rewarding effects has been well studied, the …
Although the neurobiology of cocaine's rewarding effects has been well studied, the …
Corticotropin-releasing factor antagonist attenuates the “anxiogenic-like” effect in the defensive burying paradigm but not in the elevated plus-maze following chronic …
AM Basso, M Spina, J Rivier, W Vale, GF Koob - Psychopharmacology, 1999 - Springer
Rationale: Chronic cocaine abuse is associated with the development of anxiogenic states
in humans. Corticotropin-releasing factor (CRF) is an endogenous neurotropic factor well …
in humans. Corticotropin-releasing factor (CRF) is an endogenous neurotropic factor well …
A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine …
S Erb, N Salmaso, D Rodaros, J Stewart - Psychopharmacology, 2001 - Springer
Rationale: We reported previously that bilateral injection of a corticotropin-releasing factor
(CRF)-receptor antagonist, D-Phe CRF 12–41, into the bed nucleus of the stria terminalis …
(CRF)-receptor antagonist, D-Phe CRF 12–41, into the bed nucleus of the stria terminalis …
Corticotropin-releasing factor receptor blockade enhances conditioned aversive properties of cocaine in rats
SC Heinrichs, A Klaassen, GF Koob, G Schulteis… - …, 1998 - Springer
The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like
and aversive responses to stressors may be particularly relevant for dependence and …
and aversive responses to stressors may be particularly relevant for dependence and …
Brain corticotropin-releasing factor mediates 'anxiety-like'behavior induced by cocaine withdrawal in rats
Z Sarnyai, E Biro, J Gardi, M Vecsernyés, J Julesz… - Brain research, 1995 - Elsevier
Anxiety is a key symptom of the cocaine withdrawal syndrome in human addicts, and it is
considered to be one of the major factors in precipitating relapse to chronic cocaine abuse …
considered to be one of the major factors in precipitating relapse to chronic cocaine abuse …
Conditioned increases in anxiogenic-like behavior following exposure to contextual stimuli associated with cocaine are mediated by corticotropin-releasing factor
AC DeVries, A Pert - Psychopharmacology, 1998 - Springer
Although cocaine is a powerful reinforcer, it has been reported to produce anxiety in humans
and anxiogenic-like behavior in animals. The goal of this study was three-fold:(1) to …
and anxiogenic-like behavior in animals. The goal of this study was three-fold:(1) to …
In vivo CRF release in rat amygdala is increased during cocaine withdrawal in self‐administering rats
RM Richter, F Weiss - Synapse, 1999 - Wiley Online Library
Previous studies have suggested a role for corticotropin‐releasing factor (CRF) in the central
nucleus of the amygdala (CeA) in the aversive and anxiogenic effects of withdrawal from …
nucleus of the amygdala (CeA) in the aversive and anxiogenic effects of withdrawal from …
Cocaine pre-exposure enhances CRF-induced expression of c-fos mRNA in the central nucleus of the amygdala: an effect that parallels the effects of cocaine pre …
S Erb, D Funk, AD Lê - Neuroscience letters, 2005 - Elsevier
There is evidence that cocaine pre-exposure produces changes in the responsivity of central
corticotropin-releasing factor (CRF) systems and that these systems mediate some of the …
corticotropin-releasing factor (CRF) systems and that these systems mediate some of the …
A study of the lasting effects of cocaine pre-exposure on anxiety-like behaviors under baseline conditions and in response to central injections of corticotropin …
S Erb, H Kayyali, K Romero - Pharmacology Biochemistry and Behavior, 2006 - Elsevier
Anxiety-like behaviors emerge with repeated exposure to and short-term withdrawal from
cocaine. The stress-related neuropeptide, corticotropin-releasing factor (CRF), has been …
cocaine. The stress-related neuropeptide, corticotropin-releasing factor (CRF), has been …