The misuse of prescription opiates is on the rise with combination therapies (eg
acetaminophen or NSAIDs) resulting in severe liver and kidney damage. In recent years …

The cannabinoid 1 receptor and cannabinoid 2 receptor can both be targeted in the
treatment of pain; yet, they have some important differences. Cannabinoid 1 receptor is …

Rationale Dozens of preclinical studies have reported cannabinoid agonist potentiation of
the analgesic effects of μ-opioid agonists. Objectives The aim of this study was to determine …

The opioid crisis has underscored the urgent need to identify safe and effective therapeutic
strategies to overcome opioid-induced liabilities. We recently reported that LY2828360, a …

The endogenous opioid and cannabinoid receptor systems are widely distributed and co-
localized throughout central and peripheral nervous system regions. A large body of …

Opioid analgesics represent a critical treatment for chronic pain in the analgesic ladder of
the World Health Organization. However, their use can result in a number of unwanted side …

Cannabinoid receptor agonists, such as Δ9-tetrahydrocannabinol (Δ9-THC), enhance the
antinociceptive effects of μ-opioid receptor agonists, which suggests that combining …

Morphine is a potent opioid analgesic used to alleviate moderate or severe pain, but the
development of drug tolerance and dependence limits its use in pain management. Previous …

Opiates and exogenous cannabinoids, both potent analgesics used for the treatment of
patients with neuropathic pain, bind to and activate class A G-protein-coupled receptors …

Opioid drugs are a first-line treatment for severe acute pain and other chronic pain
conditions, but long-term opioid drug use produces opioid-induced hyperalgesia (OIH). Co …