Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists
SA Grenald, MA Young, Y Wang, MH Ossipov… - …, 2017 - Elsevier
The misuse of prescription opiates is on the rise with combination therapies (eg
acetaminophen or NSAIDs) resulting in severe liver and kidney damage. In recent years …
acetaminophen or NSAIDs) resulting in severe liver and kidney damage. In recent years …
Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain
The cannabinoid 1 receptor and cannabinoid 2 receptor can both be targeted in the
treatment of pain; yet, they have some important differences. Cannabinoid 1 receptor is …
treatment of pain; yet, they have some important differences. Cannabinoid 1 receptor is …
Cannabinoid modulation of opioid analgesia and subjective drug effects in healthy humans
S Babalonis, MR Lofwall, PA Sloan, PA Nuzzo… - …, 2019 - Springer
Rationale Dozens of preclinical studies have reported cannabinoid agonist potentiation of
the analgesic effects of μ-opioid agonists. Objectives The aim of this study was to determine …
the analgesic effects of μ-opioid agonists. Objectives The aim of this study was to determine …
The cannabinoid CB2 receptor agonist LY2828360 synergizes with morphine to suppress neuropathic nociception and attenuates morphine reward and physical …
The opioid crisis has underscored the urgent need to identify safe and effective therapeutic
strategies to overcome opioid-induced liabilities. We recently reported that LY2828360, a …
strategies to overcome opioid-induced liabilities. We recently reported that LY2828360, a …
Therapeutic potential of opioid/cannabinoid combinations in humans: Review of the evidence
S Babalonis, SL Walsh - European Neuropsychopharmacology, 2020 - Elsevier
The endogenous opioid and cannabinoid receptor systems are widely distributed and co-
localized throughout central and peripheral nervous system regions. A large body of …
localized throughout central and peripheral nervous system regions. A large body of …
Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing …
Opioid analgesics represent a critical treatment for chronic pain in the analgesic ladder of
the World Health Organization. However, their use can result in a number of unwanted side …
the World Health Organization. However, their use can result in a number of unwanted side …
Impact of efficacy at the μ-opioid receptor on antinociceptive effects of combinations of μ-opioid receptor agonists and cannabinoid receptor agonists
DR Maguire, CP France - Journal of Pharmacology and Experimental …, 2014 - ASPET
Cannabinoid receptor agonists, such as Δ9-tetrahydrocannabinol (Δ9-THC), enhance the
antinociceptive effects of μ-opioid receptor agonists, which suggests that combining …
antinociceptive effects of μ-opioid receptor agonists, which suggests that combining …
Cannabinoid–opioid interactions during neuropathic pain and analgesia
I Bushlin, R Rozenfeld, LA Devi - Current opinion in pharmacology, 2010 - Elsevier
Opiates and exogenous cannabinoids, both potent analgesics used for the treatment of
patients with neuropathic pain, bind to and activate class A G-protein-coupled receptors …
patients with neuropathic pain, bind to and activate class A G-protein-coupled receptors …
[HTML][HTML] Effects of cannabinoid type 2 receptor agonist AM1241 on morphine-induced antinociception, acute and chronic tolerance, and dependence in mice
M Zhang, L Dong, H Zou, J Li, Q Li, G Wang, H Li - The Journal of Pain, 2018 - Elsevier
Morphine is a potent opioid analgesic used to alleviate moderate or severe pain, but the
development of drug tolerance and dependence limits its use in pain management. Previous …
development of drug tolerance and dependence limits its use in pain management. Previous …
Positive allosteric modulation of the cannabinoid type-1 receptor (CB1R) in periaqueductal gray (PAG) antagonizes anti-nociceptive and cellular effects of a mu-opioid …
Opioid drugs are a first-line treatment for severe acute pain and other chronic pain
conditions, but long-term opioid drug use produces opioid-induced hyperalgesia (OIH). Co …
conditions, but long-term opioid drug use produces opioid-induced hyperalgesia (OIH). Co …
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