Pain and aging: A unique challenge in neuroinflammation and behavior

SP Singh, J Guindon, PH Mody, G Ashworth… - Molecular …, 2023 - journals.sagepub.com
Chronic pain is one of the most common, costly, and potentially debilitating health issues
facing older adults, with attributable costs exceeding $600 billion annually. The prevalence …

[HTML][HTML] The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain

M Millecamps, XQ Shi, M Piltonen, S Echeverry… - Neurobiology of …, 2020 - Elsevier
Older individuals have an elevated risk for chronic pain as half of all individuals over 65
years old have at least one chronic pain condition. Unfortunately, relevant assessment tools …

[HTML][HTML] Chronic pain in the elderly: mechanisms and distinctive features

A Tinnirello, S Mazzoleni, C Santi - Biomolecules, 2021 - mdpi.com
Background: Chronic pain is a major issue affecting more than 50% of the older population
and up to 80% of nursing homes residents. Research on pain in the elderly focuses mainly …

The effects of age on pain sensitivity: preclinical studies

RP Yezierski - Pain medicine, 2012 - academic.oup.com
Objective. Preclinical studies of pain and aging represent an area of research where
considerations of age, strain, gender, and method of behavioral assessment are but some of …

[HTML][HTML] Chronic pain in the elderly: mechanisms and perspectives

APA Dagnino, MM Campos - Frontiers in Human Neuroscience, 2022 - frontiersin.org
Chronic pain affects a large part of the population causing functional disability, being often
associated with coexisting psychological disorders, such as depression and anxiety …

[HTML][HTML] The link between chronic pain and Alzheimer's disease

S Cao, DW Fisher, T Yu, H Dong - Journal of neuroinflammation, 2019 - Springer
Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative
disorders such as Alzheimer's disease (AD). Although studies indicate that chronic pain …

[HTML][HTML] Pain and aging: the emergence of a new subfield of pain research

L Gagliese - The Journal of Pain, 2009 - Elsevier
The pain and aging subfield has grown dramatically, including a 6-fold increase in
publications over the last 2 decades. This subfield is based on the assumption that pain in …

Nociceptor sensitization depends on age and pain chronicity

AD Weyer, KJ Zappia, SR Garrison, CL O'Hara… - Eneuro, 2016 - eneuro.org
Peripheral inflammation causes mechanical pain behavior and increased action potential
firing. However, most studies examine inflammatory pain at acute, rather than chronic time …

[HTML][HTML] Sex differences in psychophysical and neurophysiological responses to pain in older adults: a cross-sectional study

TB Monroe, JC Gore, SP Bruehl… - Biology of Sex …, 2015 - Springer
Background Neuroimaging studies in younger adults have demonstrated sex differences in
brain processing of painful experimental stimuli. Such differences may contribute to findings …

Age and sex drive differential behavioral and neuroimmune phenotypes during postoperative pain

NL Dos Santos, ME Lenert, ZW Castillo, PH Mody… - Neurobiology of …, 2023 - Elsevier
Surgical procedures in the geriatric population are steadily increasing, driven by improved
healthcare technologies and longer lifespans. However, effective postoperative pain …