Histone acetylation marks are written by histone acetyltransferases (HATs) and read by
bromodomains (BrDs), and less commonly by other protein modules. These proteins …

The post-translational modification of histones plays an important role in chromatin
regulation, a process that insures the fidelity of gene expression and other DNA …

Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto
lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors …

Acetylation of lysine residues is a post-translational modification with broad relevance to
cellular signalling and disease biology. Enzymes that 'write'(histone acetyltransferases …

Histone acetyltransferases (HATs) directly link chromatin modification to gene activation.
Recent structure/function studies provide insights into HAT catalysis and histone binding …

▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …

Protein kinases catalyze phosphorylation, a posttranslational modification widely utilized in
cell signaling. Histone acetyltransferases (HATs) catalyze a counterpart posttranslational …

Acetylation, a key component in post-translational modification regulated by HATs and
HDACs, is relevant to many crucial cellular contexts in organisms. Based on crucial …

The role of histone acetylation as a key mechanism of transcriptional regulation has been
well established. Recent advances suggest that histone acetyltransferases also play …

Reversible protein acetylation is controlled by the opposing actions of protein lysine
acetyltransferases and deacetylations. Recent developments on the structure and …