Information concerning the relationship between pharmacokinetics and pharmacodynamics
is essential for physicians and pharmacists when deciding a dosage regimen of drug …

Information concerning the relationship between pharmacokinetics and pharmacodynamics
is es sential for physicians and pharmacists when deciding a dosage regimen of drug …

The classical analyses of dose-response data, in many instances, fail to identify the
minimum effective dose of a new drug. To individualize doses further for drugs with high …

Objective: The aim of this research is to understand the level of utilization of population
pharmacokinetics (PPK) in drug development in the United States of America (US) and …

目的 とした効果を引き出す最適な投与量, 投与間隔を明らかにすることができます. PK モ
デルについては一般によく理解されていますので, PD モ デルについて説明し, PK/PD モ …

Abstract Pharmacokinetic/pharmacodynamic (PK/PD)-modeling links dose-concentration
relationships (PK) and concentration-effect relationships (PD), thereby facilitating the …

医薬品の開発は非臨床試験・臨床試験か ら得 られるデータを科学的に評価 しながら,
段階的に進められる. 最終的な医薬品の評価は, 市販後に数多くの患者さんに適用され …

There is a growing awareness that simply saying that a drug is effective (ie, the p value is
less than 0.05) is not adequate information for the optimal treatment of patients. It is …

抄録 Pharmacokinetics-Pharmacodynamics (PK-PD) is useful to understand the quantitative
relationship between drug exposure and pharmacological outcome. In recent years, results …

第 Ⅰ 相試験では, 基本的な薬物動態プロファイルを確認する目的で, 1 人の被験者から頻回に採血
を行い, 標準的な薬物動態試験法により解析する必要がある. すなわち, 多くの場合採血時間は投与 …