Multifunctional proteins are interesting candidates for nonviral gene transfer to and
expression in their target cells. Since at difference of viral vectors, the performance of these …

Integrin-mediated delivery of genes is evaluated using a synthetic vector formed by self-
assembly of DNA with an oligolysine-peptide sequence containing RGD (referred to as K16 …

We have synthesized a linear, bifunctional peptide that comprises an integrin-targeting
domain containing an arginine–glycine–aspartic acid tripeptide motif and a DNA-binding …

We report a strategy for creating a new class of protein transfection materials composed of a
functional protein core chemically modified with a dense shell of oligonucleotides. These …

BACKGROUND: Cell penetrating peptides (CPPs) have been used to deliver nucleotide-
based therapeutics to cells, but this approach has produced mixed results. Ionic interactions …

The goal of this study was to develop a gene delivery vehicle that can specifically target cell
surface receptors with low nonspecific protein adsorption and low cytotoxicity. Toward this …

We have reported previously that a basic peptide, arginine peptide, can be used as an
efficient system for delivery of foreign genes. In this work, to better understand the …

Cell penetrating peptides are useful tools for intracellular delivery of nucleic acids. Delivery
of plasmid DNA, a large nucleic acid, poses a challenge for peptide mediated transport. The …

Gene delivery into cultured cells or in vivo is a promising approach to the treatment of
diseases. Several gene delivery systems have been developed to promote gene expression …

The dramatic acceleration in identification of new nucleic-acid-based therapeutic molecules
has provided new perspectives in pharmaceutical research. However, their development is …