The blood–brain barrier (BBB) is one of the most complex and selective barriers in the
human organism. Its role is to protect the brain and preserve the homeostasis of the central …

Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a
lipid bilayer and are unable to replicate. How the EVs cross the Blood–Brain barrier (BBB) in …

Extracellular vesicles (EVs) are a subclass of biological nanoparticles secreted by most cell
types. Once secreted, EVs can travel long distances to deliver their content to target cells …

Recently, extracellular vesicles (EVs), like exosomes and microvesicles, have attracted
attention as potent carriers of intercellular communication throughout the body, including the …

Extracellular vesicles (EVs) are communication channels between different cell types in the
brain, between the brain and the periphery and vice-versa, playing a fundamental role in …

The delivery of therapeutics to the central nervous system remains a major challenge in part
due to the presence of the blood–brain barrier (BBB). Recently, cell-derived vesicles …

The restrictive nature of the blood–brain barrier (BBB) creates a major challenge for brain
drug delivery with current nanomedicines lacking the ability to cross the BBB. Extracellular …

Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the
blood and other body fluids, which disperse a variety of bioactive molecules (eg, protein …

Effective drug delivery to the CNS to achieve the desired therapeutic response is a
significant challenge in the field of drug delivery. In central nervous system (CNS), blood …

Diseases of the central nervous system (CNS) are challenging to treat, mainly due to the
blood-brain barrier (BBB), which restricts drugs in circulation from entering target regions in …