Inflammation-associated synaptic alterations as shared threads in depression and multiple sclerosis

A Bruno, E Dolcetti, FR Rizzo, D Fresegna… - Frontiers in Cellular …, 2020 - frontiersin.org
In the past years, several theories have been advanced to explain the pathogenesis of Major
Depressive Disorder (MDD), a neuropsychiatric disease that causes disability in general …

Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities

GZ Réus, LM Manosso, J Quevedo… - … & Biobehavioral Reviews, 2023 - Elsevier
Notwithstanding advances in understanding the pathophysiology of major depressive
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …

Investigating the convergent mechanisms between major depressive disorder and Parkinson's disease

AA Tran, M De Smet, GD Grant, TK Khoo… - Complex …, 2021 - karger.com
Major depressive disorder (MDD) affects more than cognition, having a temporal
relationship with neuroinflammatory pathways of Parkinson's disease (PD). Although this …

Glia in the cytokine-mediated onset of depression: fine tuning the immune response

WK Jo, Y Zhang, HM Emrich… - Frontiers in cellular …, 2015 - frontiersin.org
Major depressive disorder (MDD) is a mood disorder of multifactorial origin affecting millions
of people worldwide. The alarming estimated rates of prevalence and relapse make it a …

Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories

S Hassamal - Frontiers in psychiatry, 2023 - frontiersin.org
In a subset of patients, chronic exposure to stress is an etiological risk factor for
neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with …

Neuroinflammation and depression: A review

R Troubat, P Barone, S Leman… - European journal of …, 2021 - Wiley Online Library
Some recent clinical and preclinical evidence suggests that neuroinflammation is a key
factor that interacts with the three neurobiological correlates of major depressive disorder …

Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

A Wu, J Zhang - Journal of Neuroinflammation, 2023 - Springer
As one of most common and severe mental disorders, major depressive disorder (MDD)
significantly increases the risks of premature death and other medical conditions for patients …

Neuroinflammatory basis of depression: learning from experimental models

R Afridi, K Suk - Frontiers in cellular neuroscience, 2021 - frontiersin.org
The neuroinflammatory basis of depression encompasses the detrimental role of otherwise
supportive non-neuronal cells and neuroinflammation in hampering neuronal function …

The role of depressive subtypes within the neuroinflammation hypothesis of major depressive disorder

M Woelfer, V Kasties, S Kahlfuss, M Walter - Neuroscience, 2019 - Elsevier
Major depressive disorder (MDD) is a very common disease that affects more than 350
million people worldwide, representing an enormous socioeconomic burden. From a clinical …

[HTML][HTML] Neuroinflammation and glial cell activation in mental disorders

PGC Almeida, JV Nani, JP Oses, E Brietzke… - Brain, Behavior, & …, 2020 - Elsevier
Mental disorders (MDs) are highly prevalent and potentially debilitating complex disorders
which causes remain elusive. Looking into deeper aspects of etiology or pathophysiology …