Loss of brain glutathione has been associated with cognitive decline and neuronal death
during aging and neurodegenerative diseases. However, whether decreased glutathione …

Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …

Significance: A decline in both cognitive and motor functions is one of the characteristics of
aging. This results in changes in learning and memory, as well as deficits in balance and …

Oxidative stress is implicated in the pathogenesis of many neurodegenerative diseases,
including Parkinson's disease and Alzheimer's disease. The depletion of glutathione (GSH) …

The idea that astrocytes provide support for neurons has a long history, but whether neurons
play an instructive role in these processes is poorly understood. To address this question …

Glutathione plays an essential role in maintaining cellular redox balance, protecting cells
from oxidative stress and detoxifying xenobiotic compounds. Glutathione depletion has been …

To determine whether glutathione (GSH) loss or increased reactive oxygen species (ROS)
are more important to neuron loss, aging, and Alzheimer's disease (AD), we stressed or …

[Glutathione in cognitive function and neurodegeneration]. - Abstract - Europe PMC Sign in |
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Oxidative stress has been implicated in both normal aging and in various
neurodegenerative disorders and may be a common mechanism underlying various forms …

There is significant evidence that the pathogenesis of several neurodegenerative diseases,
including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia and amyotrophic …