Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium

VR Muthusamy, S Kannan, K Sadhaasivam… - Free Radical Biology …, 2012 - Elsevier
Oxidative stress has been implicated in the pathogenesis of cardiovascular diseases,
including myocardial hypertrophy and infarction. Although impairment of antioxidant defense …

Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training

SS Gounder, S Kannan, D Devadoss, CJ Miller… - 2012 - journals.plos.org
Aging promotes accumulation of reactive oxygen/nitrogen species (ROS/RNS) in
cardiomyocytes, which leads to contractile dysfunction and cardiac abnormalities. These …

Nrf2 protects against maladaptive cardiac responses to hemodynamic stress

J Li, T Ichikawa, L Villacorta, JS Janicki… - … , and vascular biology, 2009 - Am Heart Assoc
Background—Reactive oxygen species (ROS) play an important role in the maintenance of
cardiovascular homeostasis. The present study sought to determine whether nuclear factor …

Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation …

NS Rajasekaran, S Varadharaj… - Antioxidants & redox …, 2011 - liebertpub.com
Inheritable missense mutations in small molecular weight heat-shock proteins (HSP) with
chaperone-like properties promote self-oligomerization, protein aggregation, and pathologic …

[HTML][HTML] Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice

G Shanmugam, AK Challa, SH Litovsky, A Devarajan… - Redox biology, 2019 - Elsevier
Abstract Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2/Nrf2) is an inducible
transcription factor that is essential for maintenance of redox signaling in response to stress …

Nrf2 and Cardiovascular Defense

R Howden - Oxidative medicine and cellular longevity, 2013 - Wiley Online Library
The cardiovascular system is susceptible to a group of diseases that are responsible for a
larger proportion of morbidity and mortality than any other disease. Many cardiovascular …

The antioxidant transcription factor Nrf2 in cardiac ischemia–reperfusion injury

A Mata, S Cadenas - International journal of molecular sciences, 2021 - mdpi.com
Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that controls cellular
defense responses against toxic and oxidative stress by modulating the expression of genes …

[HTML][HTML] Nrf2 mediates redox adaptations to exercise

AJ Done, T Traustadóttir - Redox biology, 2016 - Elsevier
The primary aim of this review is to summarize the current literature on the effects of acute
exercise and regular exercise on nuclear factor erythroid 2-related factor 2 (Nrf2) activity and …

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

X He, H Kan, L Cai, Q Ma - Journal of molecular and cellular cardiology, 2009 - Elsevier
Exposure to high levels of glucose induces the production of reactive oxygen species (ROS)
in cardiomyocytes that may contribute to the development of cardiomyopathy in diabetes …

Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress

H Zhu, Z Jia, BR Misra, L Zhang, Z Cao… - Cardiovascular …, 2008 - Springer
Nuclear factor E2-related factor 2 (Nrf2) is a critical regulator of cytoprotective gene
expression. However, the role of this transcription factor in myocardiac cytoprotection …