Hydroxysteroid dehydrogenases (HSDs) interconvert potent and relatively inactive forms of
individual steroid hormones using nicotinamide cofactors NADPH/NADP+ and NADH/NAD+ …

The hydroxysteroid dehydrogenases (HSDs) interconvert pairs of weak and potent steroids,
thus serving as key enzymes in the regulation of intracellular hormone potency. These …

The task of regulating both production and activity of potent androgens and estrogens in
human physiology is largely relegated to the hydroxysteroid dehydrogenases (HSDs) …

Hydroxysteroid dehydrogenases catalyze the NAD (P)(H)-dependent oxidoreduction of
hydroxyl and oxo-functions at distinct positions of steroid hormones. This reversible reaction …

Hydroxysteroid dehydrogenases (HSDs) represent a major class of NAD (P)(H) dependent
steroid hormone oxidoreductases involved in the pre-receptor regulation of hormone action …

We have proposed that the 11β-hydroxysteroid dehydrogenase (11β-HSD) of Leydig cells
protects against glucocorticoid-induced inhibition of testosterone (T) production. However …

Leydig cells are susceptible to direct glucocorticoid-mediated inhibition of testosterone
biosynthesis but can counteract the inhibition through 11β-hydroxysteroid dehydrogenase …

Hydroxysteroid dehydrogenases (HSDs) are essential for the biosynthesis and mechanism
of action of all steroid hormones. We report the complete kinetic mechanism of a mammalian …

11β-hydroxysteroid dehydrogenase (11β-HSD) is thought to confer aldosterone specificity to
mineralocorticoid target cells by protecting the mineralocorticoid receptor (MR) from …

A monomeric 3α-hydroxysteroid dehydrogenase with a molecular weight of 34,000 was
purified to apparent homogeneity from mouse liver cytosol. The enzyme catalyzed the …