Identity determining transcription factors (TFs), or core regulatory (CR) TFs, are governed by
cell-type specific super enhancers (SEs). Drugs to selectively inhibit CR circuitry are of high …

Accessibility of the genome to DNA-binding transcription factors is regulated by proteins that
control the acetylation of amino-terminal lysine residues on nucleosomal histones …

Histone deacetylase enzymes (HDACs) are emerging cancer drug targets. They regulate
gene expression by removing acetyl groups from lysine residues in histone tails, resulting in …

Class II histone deacetylases (HDACs) repress transcription by associating with a variety of
transcription factors and corepressors. Phosphorylation of a set of conserved serine …

Histone deacetylases (HDACs) play a key role in regulating eukaryotic gene expression.
The HDAC domain, homologous to the yeast repressors RPD3 and HDA1, is considered …

HDAC1 and-2 are highly conserved enzymes and often coexist in the same coregulator
complexes. Understanding the regulation of histone deacetylase activities is extremely …

Modulation of the acetylation state of histones plays a pivotal role in the regulation of gene
expression. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from …

Histone deacetylases (HDACs) are part of transcriptional corepressor complexes and play
key roles in regulating chromatin structure. Three different classes of human HDACs have …

Proteomic analysis of histones has shown that they are subject to a superabundance of
acylations, which extend far beyond acetylation, to include: crotonylation, propionylation …

Post-translational modifications of histones, in general, and acetylation/deacetylation, in
particular, can dramatically alter gene expression in eukaryotic cells. In humans, four highly …