Immune checkpoint inhibitor therapy in patients with preexisting inflammatory bowel disease

H Abu-Sbeih, DM Faleck, B Ricciuti… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE The risk of immune checkpoint inhibitor therapy–related GI adverse events in
patients with cancer and inflammatory bowel disease (IBD) has not been well described. We …

Systematic review with meta‐analysis: safety and tolerability of immune checkpoint inhibitors in patients with pre‐existing inflammatory bowel diseases

J Meserve, A Facciorusso, AK Holmer… - Alimentary …, 2021 - Wiley Online Library
Background Immune checkpoint inhibitors may variably impact patients with pre‐existing
autoimmune diseases. Aims To evaluate the risks and outcomes of adverse events in …

Risk of gastrointestinal complications in cancer patients treated with immune checkpoint inhibitors: a meta-analysis

O Abdel-Rahman, H ElHalawani, M Fouad - Immunotherapy, 2015 - Taylor & Francis
Aim: We performed a meta-analysis of the risk of selected gastrointestinal toxicities
associated with immune checkpoint inhibitors. Patients & methods: Eligible studies included …

[HTML][HTML] Concurrent therapy with immune checkpoint inhibitors and TNFα blockade in patients with gastrointestinal immune-related adverse events

YR Badran, JV Cohen, PK Brastianos… - … for immunotherapy of …, 2019 - Springer
Background Immune checkpoint inhibitors (ICI) have demonstrated remarkable efficacy as
cancer therapeutics, however, their use remains limited due to the development of immune …

[HTML][HTML] Immune checkpoint Inhibitor–Induced diarrhea and Colitis: Incidence and Management. A systematic review and Meta-analysis

DL Nielsen, CB Juhl, IM Chen, L Kellermann… - Cancer Treatment …, 2022 - Elsevier
Abstract Background Immune checkpoint inhibitors (ICIs) have improved cancer outcomes.
However, immune-related adverse effects are common. The aim was to investigate the …

[HTML][HTML] Importance of endoscopic and histological evaluation in the management of immune checkpoint inhibitor-induced colitis

H Abu-Sbeih, FS Ali, W Luo, W Qiao, GS Raju… - … for immunotherapy of …, 2018 - Springer
Background Immune checkpoint inhibitors (ICPI) are efficacious treatments for advanced
malignancies but can result in immune mediated diarrhea and colitis (IDC). Currently, the …

Resumption of immune checkpoint inhibitor therapy after immune-mediated colitis

H Abu-Sbeih, FS Ali, AR Naqash, DH Owen… - Journal of clinical …, 2019 - ascopubs.org
PURPOSE Immune checkpoint inhibitor (ICI) therapy often is suspended because of
immune-mediated diarrhea and colitis (IMDC). We examined the rate of and risk factors for …

[HTML][HTML] Immune checkpoint inhibition-related colitis: symptoms, endoscopic features, histology and response to management

MHG Foppen, EA Rozeman, S Van Wilpe, C Postma… - ESMO open, 2018 - Elsevier
Background Immune checkpoint inhibitors are successfully introduced as anticancer
treatment. However, they may induce severe immune-related adverse events (irAEs). One of …

Management of patients with immune checkpoint inhibitor-induced enterocolitis: a systematic review

M Collins, E Soularue, L Marthey… - Clinical gastroenterology …, 2020 - Elsevier
Immune checkpoint inhibitors (ICIs) have improved the treatment of several cancers. These
drugs increase T-cell activity and the antitumor immune response but also have immune …

Gastrointestinal adverse events associated with immune checkpoint inhibitor therapy

E Rajha, P Chaftari, M Kamal, J Maamari… - Gastroenterology …, 2020 - academic.oup.com
Immunotherapy with checkpoint inhibitors has revolutionized cancer therapy and is now the
standard treatment for several different types of cancer, supported by favorable outcomes …