Protein kinases catalyse key phosphorylation reactions in signalling cascades that affect
every aspect of cell growth, differentiation and metabolism. The kinases have become prime …

Protein kinases have emerged as the most important class of targets in oncology drug
discovery because of their major roles in regulating cellular growth and survival. At least, 11 …

Kinase inhibition is a major area for therapeutic intervention against a variety of diseases
including cancer, inflammatory disorders and diabetes. While this mode of action remains …

Background: Protein kinases are essential enzymes propagating cellular signal transduction
processes and consequently emerged as central targets for drug discovery against a wide …

Protein kinases represent an attractive target in oncology drug discovery. Most of kinase
inhibitors are ATP-competitive and are called type I inhibitors. The ATP-binding pocket is …

The human genome comprises more than 500 protein kinases including serine/threonine,
tyrosine and dual specificity kinases. 1, 2 Because of the important physiological and …

Protein kinases are involved in many diseases like cancer, inflammation, cardiovascular
disease, and diabetes. They have become attractive target classes for drug development …

Background: Protein kinases are essential enzymes propagating cellular signal transduction
processes and consequently have emerged as central targets for drug discovery against a …

Over the past decade, therapeutics that target subsets of the 518 human protein kinases
have played a vital role in the fight against cancer. Protein kinases are typically targeted at …

Recent years have seen an explosion in the number of publicly available x-ray crystal
structures of protein kinases. These structures have provided a wealth of information on the …