Fungi cause serious infections in the immunocompromised and debilitated, and the
incidence of invasive mycoses has increased significantly over the last 3 decades. Slow …

Infections by opportunistic pathogenic fungi, especially Candida species, Cryptococcus
neoformans, and Aspergillus fumigatus, are a serious medical problem in …

It is now well-known that the enhanced expression of ATP binding cassette (ABC) and major
facilitator superfamily (MFS) proteins contribute to the development of tolerance to …

There are currently few antifungals in use which show efficacy against fungal diseases.
These antifungals mostly target specific components of fungal plasma membrane or its …

Resistance to antifungal drugs is an increasingly significant clinical problem. The most
common antifungal resistance encountered is efflux pump-mediated resistance of Candida …

Infections caused by opportunistic fungal pathogens have reached concerning numbers due
to the increase of the immunocrompromised human population and to the development of …

Pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi. PDR
shares several similarities with processes in bacteria and higher eukaryotes. In mammalian …

Antifungal resistance is a prominent feature in the management of invasive mycoses, with
important implications for morbidity and mortality. Microbiological resistance, the most …

Antifungal resistance is a growing concern as it poses a significant threat to public health.
Fungal infections are a significant cause of morbidity and mortality, especially in …

The enhanced efflux of antifungal drugs through ATP-binding cassette (ABC) transporters
constitutes a major cause of clinical multidrug resistance (MDR). The inhibition of drug efflux …