Antioxidant serine-(NSAID) hybrids with anti-inflammatory and hypolipidemic potency
P Theodosis-Nobelos, G Papagiouvannis, P Tziona… - Molecules, 2021 - mdpi.com
A series of L-serine amides of antioxidant acids, such as Trolox,(E)-3-(3, 5-di-tert-butyl-4-
hydroxyphenyl) acrylic acid (phenolic derivative of cinnamic acid) and 3, 5-di-tert-butyl-4 …
hydroxyphenyl) acrylic acid (phenolic derivative of cinnamic acid) and 3, 5-di-tert-butyl-4 …
Ferulic, sinapic, 3, 4-dimethoxycinnamic acid and indomethacin derivatives with antioxidant, anti-inflammatory and hypolipidemic functionality
P Theodosis-Nobelos, G Papagiouvannis, EA Rekka - Antioxidants, 2023 - mdpi.com
A series of thiomorpholine and cinnamyl alcohol derivatives, conjugated with cinnamic acid-
containing moieties, such as ferulic acid, sinapic acid and 3, 4-dimethoxycinnamic acid …
containing moieties, such as ferulic acid, sinapic acid and 3, 4-dimethoxycinnamic acid …
Design, synthesis and evaluation of antioxidant and NSAID derivatives with antioxidant, anti-inflammatory and plasma lipid lowering effects
Amides containing methyl esters of γ-aminobutyric acid (GABA), L-proline and L-tyrosine,
and esters containing 3-(pyridin-3-yl) propan-1-ol were synthesized by conjugation with 3, 5 …
and esters containing 3-(pyridin-3-yl) propan-1-ol were synthesized by conjugation with 3, 5 …
Dual antioxidant structures with potent anti-inflammatory, hypolipidemic and cytoprotective properties
P Theodosis-Nobelos, C Athanasekou… - Bioorganic & Medicinal …, 2017 - Elsevier
Novel amide derivatives of trolox, 3, 5-di-tert-butyl-4-hydroxybenzoic acid,(E)-3-(3, 5-di-tert-
butyl-4-hydroxyphenyl) acrylic acid and cinnamic acid with cysteamine and l-cysteine ethyl …
butyl-4-hydroxyphenyl) acrylic acid and cinnamic acid with cysteamine and l-cysteine ethyl …
Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-inflammatory, antioxidant, and hypocholesterolemic properties
CM Doulgkeris, D Galanakis, AP Kourounakis… - Bioorganic & medicinal …, 2006 - Elsevier
We have designed and synthesized a series of novel molecules having a residue of a
classical NSAID and an antioxidant moiety, both attached through amide bonds to a known …
classical NSAID and an antioxidant moiety, both attached through amide bonds to a known …
Novel esters and amides of nonsteroidal antiinflammatory carboxylic acids as antioxidants and antiproliferative agents
MR Hellberg, A Namil, P Delgado… - Journal of medicinal …, 1999 - ACS Publications
A series of phenolic antioxidant ester and amide derivatives of the nonsteroidal
antiinflammatory drug naproxen was designed to have both antiinflammatory and …
antiinflammatory drug naproxen was designed to have both antiinflammatory and …
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: Exploiting phenothiazine's strong antioxidant activity
AN Matralis, AP Kourounakis - Journal of medicinal chemistry, 2014 - ACS Publications
Because atherosclerosis is an inflammatory process involving a series of pathological
events such as dyslipidemia, oxidative stress, and blood clotting mechanisms, we hereby …
events such as dyslipidemia, oxidative stress, and blood clotting mechanisms, we hereby …
Anti-inflammatory and hypolipidemic effect of novel conjugates with trolox and other antioxidant acids
P Theodosis-Nobelos, PN Kourounakis… - Medicinal …, 2017 - ingentaconnect.com
Objectives: A series of esters and amides, incorporating an antioxidant residue, such as
trolox or caffeic acid, and various moieties with different biological activities, were …
trolox or caffeic acid, and various moieties with different biological activities, were …
Heterocyclic aryl (phenyl) acetic acid and aryl acetohydroxamic acids as antiinflammatory-antioxidant agents and inhibitors of lipoxygenase and serine proteases
A Michaelidou, D Hadjipavlou-Litina… - Medicinal …, 2007 - ingentaconnect.com
Taking into account that compounds bearing a thiazolyl, pyridyl and indolyl, moieties
possess a wide spectrum of biological activities which is related to their capacity to transfer …
possess a wide spectrum of biological activities which is related to their capacity to transfer …
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity
P Theodosis-Nobelos, M Kourti, A Gavalas… - Bioorganic & Medicinal …, 2016 - Elsevier
Novel amides of non steroidal anti-inflammatory drugs (NSAIDs), α-lipoic acid and indole-3-
acetic acid with thiomorpholine were synthesised by a simple method and at high yields (60 …
acetic acid with thiomorpholine were synthesised by a simple method and at high yields (60 …