Introduction Neuropathic pain is a debilitating condition. The importance of neuroimmune
interactions in neuropathic pain has been evidenced by the involvement of different immune …

Neuropathic pain can have a major effect on quality of life but current therapies are often
inadequate. Growing evidence suggests that neuropathic pain induced by nerve damage is …

Background Neuropathic pain is caused by neural damage or dysfunction and neuropathic
pain‐related symptoms are resistant to conventional analgesics. Neuroinflammation due to …

Neuropathic pain is a pathological symptom experienced worldwide by patients suffering
with nervous system dysfunction caused by various diseases. Treatment of neuropathic pain …

Molecular and cellular interactions among spinal dorsal horn neurons and microglia, the
resident macrophages of the central nervous system, contribute to the induction and …

Neuronal plasticity along the pathway for sensory transmission including the spinal cord and
cortex plays an important role in chronic pain, including inflammatory and neuropathic pain …

It has been well documented that Wallerian degeneration following nerve injury is
associated with inflammatory reaction. Such local inflammation contributes to the …

Background The NF-κB pathway and chemokine (CC motif) ligand 5 (CCL5) are involved in
pain modulation; however, the precise mechanisms of their interactions in chronic …

The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …

Neuropathic pain resulting from damage or dysfunction of the nervous system is a highly
debilitating chronic pain state and is often resistant to currently available treatments. It has …