Sympathetic neurons depend on target-derived neurotrophic cues to control their survival
and growth. However, whether sympathetic innervation contributes reciprocally to the …

Pancreatic innervation is being viewed with increasing interest with respect to pancreatic
disease. At the same time, relatively little is currently known about innervation dynamics …

The autonomic nervous system regulates hormone secretion from the endocrine pancreas,
the islets of Langerhans, thus impacting glucose metabolism. The parasympathetic and …

The autonomic nervous system is thought to modulate blood glucose homeostasis by
regulating endocrine cell activity in the pancreatic islets of Langerhans. The role of islet …

The autonomic nervous system affects glucose metabolism partly through its connection to
the pancreatic islet. Since its discovery by Paul Langerhans, the precise innervation patterns …

Intracellular glucose signalling pathways control the secretion of glucagon and insulin by
pancreatic islet α‐and β‐cells, respectively. However, glucose also indirectly controls the …

The central and peripheral nervous systems play critical roles in regulating pancreatic islet
function and glucose metabolism. Over the last century, in vitro and in vivo studies along …

Aims/hypothesis Sympathetic nerves influence islet hormone levels in the circulation.
Insights into islet sympathetic innervation and its remodelling in diabetes may impact future …

The pancreatic islet secretes the hormones insulin and glucagon to regulate glucose
metabolism. To generate an adequate secretory response, islet endocrine cells must receive …

Dysregulation of glucagon secretion in type 1 diabetes (T1D) involves hypersecretion during
postprandial states, but insufficient secretion during hypoglycemia. The sympathetic nervous …