[HTML][HTML] The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis

T Yoshimura, C Li, Y Wang, A Matsukawa - Cellular & Molecular …, 2023 - nature.com
Breast cancer is the most prevalent cancer worldwide, and metastasis is the leading cause
of death in cancer patients. Human monocyte chemoattractant protein-1 (MCP-1/CCL2) was …

The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?

T Yoshimura - Cellular & molecular immunology, 2018 - nature.com
Macrophages are one of the most abundant leukocyte populations infiltrating tumor tissues
and can exhibit both tumoricidal and tumor-promoting activities. In 1989, we reported the …

Monocyte chemoattractant protein-1 serum levels in patients with breast cancer

A Lebrecht, C Grimm, T Lantzsch, E Ludwig, L Hefler… - Tumor Biology, 2004 - karger.com
The chemokine monocyte chemoattractant protein (MCP)-1 is thought to be involved in
breast carcinogenesis. We evaluated MCP-1 serum levels in patients with breast cancer (n …

[HTML][HTML] Induction of monocyte chemoattractant proteins in macrophages via the production of granulocyte/macrophage colony-stimulating factor by breast cancer cells

T Yoshimura, T Imamichi, JM Weiss, M Sato… - Frontiers in …, 2016 - frontiersin.org
Monocyte chemoattractant protein-1 (MCP-1)/CCL2 plays an important role in the initiation
and progression of cancer. We previously reported that in 4T1 murine breast cancer, non …

Significant correlation of monocyte chemoattractant protein‐1 expression with neovascularization and progression of breast carcinoma

H Saji, M Koike, T Yamori, S Saji… - … Journal of the …, 2001 - Wiley Online Library
BACKGROUND Macrophages often infiltrate into solid tumor tissues. Tumor‐associated
macrophages (TAMs) are known to play a crucial role in tumor progression. Monocyte …

[HTML][HTML] Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells

T Yoshimura, OMZ Howard, T Ito, M Kuwabara… - PloS one, 2013 - journals.plos.org
MCP-1/CCL2 plays an important role in the initiation and progression of cancer. Since tumor
cells produce MCP-1, they are considered to be the main source of this chemokine. Here …

Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment

T Kuroda, Y Kitadai, S Tanaka, X Yang, N Mukaida… - Clinical cancer …, 2005 - AACR
Abstract Purpose: Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that has
various roles in tumor development and progression. We previously reported that …

Concomitant expression of the chemokines RANTES and MCP-1 in human breast cancer: a basis for tumor-promoting interactions

G Soria, N Yaal-Hahoshen, E Azenshtein, S Shina… - Cytokine, 2008 - Elsevier
The chemokines RANTES (CCL5) and MCP-1 (CCL2) were suggested to contribute,
independently, to breast malignancy. In the present study, we asked if the two chemokines …

Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma

A Sica, A Saccani, B Bottazzi, S Bernasconi… - The Journal of …, 2000 - journals.aai.org
Abstract Monocyte chemotactic protein-1 (MCP-1, CCL2) is an important determinant of
macrophage infiltration in tumors, ovarian carcinoma in particular. MCP-1 binds the …

Monocyte chemoattractant protein inhibits the generation of tumor-reactive T cells

L Peng, S Shu, JC Krauss - Cancer Research, 1997 - AACR
The adoptive transfer of tumor-sensitized T cells can eradicate disseminated malignancy in
murine animal models. T cells must be sensitized to tumor antigens in vivo to acquire …