[HTML][HTML] The roles of the SOX2 protein in the development of esophagus and esophageal squamous cell carcinoma, and pharmacological target for therapy
J Zhang, Z Wang, H Zhao, Y Wei, Y Zhou… - Biomedicine & …, 2023 - Elsevier
SOX2 is a transcription factor belonging to the SOX gene family, whose activity has been
associated with the maintenance of the stemness and self-renewal of embryonic stem cells …
associated with the maintenance of the stemness and self-renewal of embryonic stem cells …
[HTML][HTML] Functional characterization of SOX2 as an anticancer target
S Zhang, X Xiong, Y Sun - Signal transduction and targeted therapy, 2020 - nature.com
SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …
[HTML][HTML] Paradoxical role of SOX2 in gastric cancer
Sox2 is a critical regulator of embryogenesis and necessary for cellular reprogramming. It
also plays an important role in tissue homeostasis and regeneration, maintaining the …
also plays an important role in tissue homeostasis and regeneration, maintaining the …
The multiple roles for Sox2 in stem cell maintenance and tumorigenesis
K Liu, B Lin, M Zhao, X Yang, M Chen, A Gao, F Liu… - Cellular signalling, 2013 - Elsevier
The Sry-containing protein Sox2 initially was known to regulate the self-renewal of the
mouse and human embryonic stem cells (ESCs). It is also important for the maintenance of …
mouse and human embryonic stem cells (ESCs). It is also important for the maintenance of …
[HTML][HTML] SOX2 in development and cancer biology
D Novak, L Hüser, JJ Elton, V Umansky… - Seminars in cancer …, 2020 - Elsevier
The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …
role in maintaining the stemness of embryonic cells and various adult stem cell populations …
SOX 2 promotes tumor growth of esophageal squamous cell carcinoma through the AKT/mammalian target of rapamycin complex 1 signaling pathway
Y Gen, K Yasui, T Nishikawa, T Yoshikawa - Cancer science, 2013 - Wiley Online Library
The transcription factor SOX 2 is essential for the maintenance of embryonic stem cells and
normal development of the esophagus. Our previous study revealed that the SOX2 gene is …
normal development of the esophagus. Our previous study revealed that the SOX2 gene is …
[HTML][HTML] SOX2-associated signaling pathways regulate biological phenotypes of cancers
LN Ding, YY Yu, CJ Ma, CJ Lei, HB Zhang - Biomedicine & …, 2023 - Elsevier
SOX2 is a transcription factor involved in multiple stages of embryonic development. In
related reports, SOX2 was found to be abnormally expressed in tumor tissues and correlated …
related reports, SOX2 was found to be abnormally expressed in tumor tissues and correlated …
The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells
K Hütz, R Mejías-Luque, K Farsakova, M Ogris… - …, 2014 - academic.oup.com
Gastric cancer (GC) is still one of the most common causes of cancer-related death
worldwide, which is mainly attributable to late diagnosis and poor treatment options …
worldwide, which is mainly attributable to late diagnosis and poor treatment options …
Two novel splice variants of SOX2OT, SOX2OT-S1, and SOX2OT-S2 are coupregulated with SOX2 and OCT4 in esophageal squamous cell carcinoma
Long noncoding RNAs (lncRNAs) have emerged as new regulators of stem cell pluripotency
and tumorigenesis. The SOX2 gene, a master regulator of pluripotency, is embedded within …
and tumorigenesis. The SOX2 gene, a master regulator of pluripotency, is embedded within …
[HTML][HTML] SOX2 and cancer: current research and its implications in the clinic
K Weina, J Utikal - Clinical and translational medicine, 2014 - Springer
SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …
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