Innate immune activation and CD4+ T cell priming during respiratory fungal infection

A Rivera, G Ro, HL Van Epps, T Simpson, I Leiner… - Immunity, 2006 - cell.com
Aspergillus fumigatus is a mold that causes a spectrum of diseases, including lethal lung
infections in immunocompromised humans and allergic asthma in atopic individuals. T …

[HTML][HTML] Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection

TM Hohl, A Rivera, L Lipuma, A Gallegos, C Shi… - Cell host & …, 2009 - cell.com
Aspergillus fumigatus, a ubiquitous fungus, causes invasive disease in
immunocompromised humans. Although monocytes and antigen-specific CD4 T cells …

Helper T‐cell responses and pulmonary fungal infections

AJ McDermott, BS Klein - Immunology, 2018 - Wiley Online Library
The mucosal surface of the respiratory tract encounters microbes, such as fungal particles,
with every inhaled breath. When pathogenic fungi breach the physical barrier and innate …

Distinct CD4+-T-Cell Responses to Live and Heat-Inactivated Aspergillus fumigatus Conidia

A Rivera, HL Van Epps, TM Hohl, G Rizzuto… - Infection and …, 2005 - Am Soc Microbiol
Aspergillus fumigatus is an important fungal pathogen that causes invasive pulmonary
disease in immunocompromised hosts. Respiratory exposure to A. fumigatus spores also …

Coevolution of TH1, TH2, and TH17 Responses during Repeated Pulmonary Exposure to Aspergillus fumigatus Conidia

BJ Murdock, AB Shreiner, RA McDonald… - Infection and …, 2011 - Am Soc Microbiol
Aspergillus fumigatus, a ubiquitous airborne fungus, can cause invasive infection in
immunocompromised individuals but also triggers allergic bronchopulmonary aspergillosis …

IL-1α Signaling Is Critical for Leukocyte Recruitment after Pulmonary Aspergillus fumigatus Challenge

AK Caffrey, MM Lehmann, JM Zickovich… - PLoS …, 2015 - journals.plos.org
Aspergillus fumigatus is a mold that causes severe pulmonary infections. Our knowledge of
how A. fumigatus growth is controlled in the respiratory tract is developing, but still limited …

Necessary and sufficient role for T helper cells to prevent fungal dissemination in allergic lung disease

PC Porter, L Roberts, A Fields, M Knight… - Infection and …, 2011 - Am Soc Microbiol
Mucosal immune responses to fungal infection range from T helper type 2 (Th2) cell-directed
allergic inflammation to Th1-predominant neutrophilic inflammation, but the mechanisms …

Dynamic Immune Cell Recruitment After Murine Pulmonary Aspergillus fumigatus Infection under Different Immunosuppressive Regimens

N Kalleda, J Amich, B Arslan, S Poreddy… - Frontiers in …, 2016 - frontiersin.org
Humans are continuously exposed to airborne spores of the saprophytic fungus Aspergillus
fumigatus. However, in healthy individuals pulmonary host defense mechanisms efficiently …

Inflammatory monocytes orchestrate innate antifungal immunity in the lung

V Espinosa, A Jhingran, O Dutta, S Kasahara… - PLoS …, 2014 - journals.plos.org
Aspergillus fumigatus is an environmental fungus that causes invasive aspergillosis (IA) in
immunocompromised patients. Although-CC-chemokine receptor-2 (CCR2) and Ly6C …

TNF-α from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection

M Fei, S Bhatia, TB Oriss… - Proceedings of the …, 2011 - National Acad Sciences
Aspergillus fumigatus is commonly associated with allergic bronchopulmonary aspergillosis
in patients with severe asthma in which chronic airway neutrophilia predicts a poor outcome …