Our understanding of the regulation of appetite has improved considerably over the last few
decades. Recent work, stimulated by efforts aimed at curbing the current obesity epidemic …

In the field of obesity research, two separate lines of study have emerged which explore the
mechanism by which food intake is regulated: short‐term control of food intake, and the …

Peptide hormones released from the gastrointestinal tract communicate information about
the current state of energy balance to the brain. These hormones regulate appetite and …

Obesity is one of the major challenges to human health worldwide; however, there are
currently no effective pharmacological interventions for obesity. Recent studies have …

Our understanding of the physiological systems that regulate food intake and body weight
has increased immensely over the past decade. Brain centres, including the hypothalamus …

The overwhelming increase in the prevalence of overweight and obesity in recent years
represents one of the greatest threats to the health of the developed world. Among current …

The brain, particularly the hypothalamus and brainstem, monitors and integrates circulating
metabolic signals, including gut hormones. Gut–brain communication is also mediated by …

Obesity is highly prevalent in industralized countries and is increasing worldwide. It is also a
major risk factor for type 2 diabetes, hypertension, coronary artery disease and certain …

The worldwide increase in the incidence of obesity is a consequence of a positive energy
balance, with energy intake exceeding expenditure. The signalling systems that underlie …

The obesity epidemic is fast becoming one of the leading causes of mortality and morbidity
worldwide. Over the past 30 years, gastrointestinal hormones have been increasingly …