Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, but the
pathogenesis is not completely understood. The application of metabolomics could help in …

Background The molecular mechanisms involved in atrial fibrillation are not well known. We
used plasma metabolomics to investigate if we could identify novel biomarkers and …

Introduction and objectives Fatty acid metabolic dysregulation in mitochondria is a common
mechanism involved in the development of heart failure (HF) and atrial fibrillation (AF). We …

Previous studies have shown several metabolic biomarkers to be associated with prevalent
and incident atrial fibrillation (AF), but the results have not been replicated. We investigated …

We have previously identified associations of 2 circulating secondary bile acids
(glycocholenate and glycolithocolate sulfate) with atrial fibrillation (AF) risk in 1,919 blacks in …

Background Atrial fibrillation (AF) is a common arrhythmia. Application of metabolomic
approaches, which may identify novel pathways and biomarkers of disease risk, to a …

Background Few studies have examined the associations of trimethylamine-N-oxide (TMAO)
and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial …

Background Tricarboxylic acid (TCA) cycle deregulation may predispose to cardiovascular
diseases, but the role of TCA cycle-related metabolites in the development of atrial …

Background & aims Circulating levels of acylcarnitines (ACs) have been associated with the
risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have …

Background The American Heart Association's framework “ideal cardiovascular
health”(CVH) focuses on modifiable risk factors to reduce cardiovascular disease (CVD) …