Induction of cytochrome P450 as a biomarker for environmental contamination in aquatic ecosystems

TD Bucheli, K Fent - Critical reviews in environmental science and …, 1995 - Taylor & Francis
Representing toxicant‐induced changes in biological systems, biomarkers can serve as
linkers between contamination (cause) and biological effects, and therefore provide unique …

Use of cytochrome P450 1A (CYP1A) in fish as a biomarker of aquatic pollution

A Goksøyr - Toxicology in Transition: Proceedings of the 1994 …, 1995 - Springer
Abstract Development of diagnostic and predictive biomarkers for use in pollution monitoring
depends on a fundamental characterization and understanding of the mechanisms and …

Induction of cytochrome P4501A (CYP1A) in fish a biomarker for environmental pollution

B M. Nilsen, K Berg, A GoksoØr - Cytochrome P450 Protocols, 1998 - Springer
Inducible proteins are attractive candidates for biomarkers-ie biological responses that
reflect exposure to, or effects of, environmental pollutants in an organism (1). Blomarkers are …

Cytochrome P4501A and associated mixed-function oxidase induction in fish as a biomarker for toxic carcinogenic pollutants in the aquatic environment

E Arinç, A Sen, A Bozcaarmutlu - Pure and applied chemistry, 2000 - degruyter.com
Polycyclic aromatic hydrocarbons (PAHs), dioxins, dibenzofurans, and polychlorinated
biphenyls (PCBs) present in polluted environment induce cytochrome P4501A (CYP1A) …

Immunochemical approaches to studies of CYP1A localization and induction by xenobiotics in fish

A Goksøyr, AM Husøy - Fish ecotoxicology, 1998 - Springer
There is an increasing understanding that polynuclear aromatic hydrocarbons (PAHs) and
organochlorine compounds (like polychlorinated biphenyls (PCBs), certain pesticides and …

Caged and wild fish: Induction of hepatic cytochrome P‐450 (CYP1A1) as an environmental biomonitor

ML Haasch, JJ Lech, R Prince… - … and Chemistry: An …, 1993 - Wiley Online Library
Hepatic monooxygenase activity can be induced by many different environmental chemical
contaminants, and measurement of this activity has been proposed as an environmental …

Biotechnology and pollution monitoring: use of molecular biomarkers in the aquatic environment

DR Livingstone - Journal of Chemical Technology & …, 1993 - Wiley Online Library
Metals and organic contaminants, present in the water‐column, sediment or food, are readily
accumulated by aquatic organisms. Exposure to and toxic effects of contaminants can be …

Molecular biomarkers and toxic consequences of impact by organic pollution in aquatic organisms

DR Livingston, L Förlin, SG George - 1994 - aquadocs.org
Organic contaminants are readily bioaccumulated by aquatic organisms. Exposure to and
toxic effects of contaminants can be measured in terms of the biochemical responses of the …

A field evaluation of cytochrome P4501A as a biomarker of contaminant exposure in three species of flatfish

TK Collier, BF Anulacion, JE Stein… - … and Chemistry: An …, 1995 - Wiley Online Library
A study was conducted over the course of a year to determine the induction of hepatic
cytochrome P4501A (CYP1A) in three species of benthic fish collected from a contaminated …

Cytochrome P-450 monooxygenase systems in aquatic species: carcinogen metabolism and biomarkers for carcinogen and pollutant exposure.

JJ Stegeman, JJ Lech - Environmental health perspectives, 1991 - ehp.niehs.nih.gov
High levels of polynuclear aromatic hydrocarbon (PAH) carcinogens commonly occur in
aquatic systems where neoplasms arise in fish and other animals. Enzymes that transform …