The biology of the human brain, and in particular the dynamic interactions between the
numerous cell types and regions of the central nervous system, has been difficult to study …

Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …

The study of human brain physiology, including cellular interactions in normal and disease
conditions, has been a challenge due to its complexity and unavailability. Induced …

Understanding etiology of human neurological and psychiatric diseases is challenging.
Genomic changes, protracted development, and histological features unique to human brain …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

The ability to reproduce early stages of human neurodevelopment in the laboratory is one of
the most exciting fields in modern neuroscience. The inaccessibility of the healthy human …

Organoids are 3D cell culture systems derived from human pluripotent stem cells that
contain tissue resident cell types and reflect features of early tissue organization. Neural …

Understanding the development and dysfunction of the human brain is a major goal of
neurobiology. Much of our current understanding of human brain development has been …

The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …

Scientists have been fascinated by the human brain for centuries, yet knowledge of the
cellular and molecular events that build the human brain during embryogenesis and of how …