The protein C pathway provides multiple important functions to maintain a regulated balance
between hemostasis and host defense systems in response to vascular and inflammatory …

Protein C is best known for its mild deficiency associated with venous thrombosis risk and
severe deficiency associated with neonatal purpura fulminans. Activated protein C (APC) …

Activated protein C (APC) plays active roles in preventing progression of a number of
disease processes. These include thrombosis due to its direct anticoagulant activity which is …

Protein C is a vitamin K-dependent anticoagulant serine protease zymogen in plasma which
upon activation by the thrombin-thrombomodulin complex down-regulates the coagulation …

The direct cytoprotective activities of activated protein C (APC) on cells convey therapeutic,
relevant, beneficial effects in injury and disease models in vivo and require the endothelial …

Plasma protein C is a serine protease zymogen that is transformed into the active, trypsin-
like protease, activated protein C (APC), which can exert multiple activities. For its …

Activated protein C (APC) has anti-inflammatory and vascular protective effects independent
of anticoagulation. We previously identified the prototypical thrombin receptor, protease …

The protein C system is an important natural anticoagulant mechanism mediated by
activated protein C (APC) that regulates the activity of factors VIIIa and Va. Besides well …

Activated protein C (APC), a natural anticoagulant protease, can trigger cellular responses
via protease-activated receptor-1 (PAR1), a G protein-coupled receptor for thrombin …

Activated protein C (APC) has endothelial barrier protective effects that require binding to
endothelial protein C receptor (EPCR) and cleavage of protease activated receptor-1 …