Vasculature organotropism in drug delivery
Over the past decades, there has been an exponential increase in the development of
preclinical and clinical nanodelivery systems, and recently, an accelerating demand to …
preclinical and clinical nanodelivery systems, and recently, an accelerating demand to …
Targeting drug delivery in the vascular system: Focus on endothelium
PM Glassman, JW Myerson, LT Ferguson… - Advanced drug delivery …, 2020 - Elsevier
The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the
site of administration to the intended site of action. In many cases, components of the …
site of administration to the intended site of action. In many cases, components of the …
Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery
RB Huang, S Mocherla, MJ Heslinga… - Molecular membrane …, 2010 - Taylor & Francis
Vascular-targeted drug delivery systems could provide more efficient and effective
pharmaceutical interventions for treating a variety of diseases including cardiovascular …
pharmaceutical interventions for treating a variety of diseases including cardiovascular …
Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm
M Howard, BJ Zern, AC Anselmo, VV Shuvaev… - ACS …, 2014 - ACS Publications
Targeted nanomedicine holds promise to find clinical use in many medical areas.
Endothelial cells that line the luminal surface of blood vessels represent a key target for …
Endothelial cells that line the luminal surface of blood vessels represent a key target for …
Overcoming in vivo barriers to targeted nanodelivery
A Chrastina, KA Massey… - Wiley Interdisciplinary …, 2011 - Wiley Online Library
Nanoparticles have been investigated as promising nanocarriers for delivery of imaging and
therapeutic agents for several decades, but have met with limited success. Although …
therapeutic agents for several decades, but have met with limited success. Although …
[HTML][HTML] Advanced drug delivery systems that target the vascular endothelium
Targeted drug delivery to endothelial cells lining the vascular lumen will provide effective,
precise andsafe therapeutic interventions for treatment of diverse disease conditions …
precise andsafe therapeutic interventions for treatment of diverse disease conditions …
Targeted endothelial nanomedicine for common acute pathological conditions
VV Shuvaev, JS Brenner, VR Muzykantov - Journal of Controlled Release, 2015 - Elsevier
Endothelium, a thin monolayer of specialized cells lining the lumen of blood vessels is the
key regulatory interface between blood and tissues. Endothelial abnormalities are …
key regulatory interface between blood and tissues. Endothelial abnormalities are …
Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles
Most clinically approved drugs (primarily small molecules or antibodies) are rapidly cleared
from circulation and distribute throughout the body. As a consequence, only a small portion …
from circulation and distribute throughout the body. As a consequence, only a small portion …
Nanoparticle targeting to diseased vasculature for imaging and therapy
A Sinha, A Shaporev, N Nosoudi, Y Lei… - … , Biology and Medicine, 2014 - Elsevier
Significant challenges remain in targeting drugs to diseased vasculature; most important
being rapid blood flow with high shear, limited availability of stable targets, and …
being rapid blood flow with high shear, limited availability of stable targets, and …
Vascular‐targeted nanocarriers: design considerations and strategies for successful treatment of atherosclerosis and other vascular diseases
WJ Kelley, H Safari, G Lopez‐Cazares… - Wiley …, 2016 - Wiley Online Library
Vascular‐targeted nanocarriers are an attractive option for the treatment of a number of
cardiovascular diseases, as they allow for more specific delivery and increased efficacy of …
cardiovascular diseases, as they allow for more specific delivery and increased efficacy of …