Over the past decades, there has been an exponential increase in the development of
preclinical and clinical nanodelivery systems, and recently, an accelerating demand to …

The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the
site of administration to the intended site of action. In many cases, components of the …

Vascular-targeted drug delivery systems could provide more efficient and effective
pharmaceutical interventions for treating a variety of diseases including cardiovascular …

Targeted nanomedicine holds promise to find clinical use in many medical areas.
Endothelial cells that line the luminal surface of blood vessels represent a key target for …

Nanoparticles have been investigated as promising nanocarriers for delivery of imaging and
therapeutic agents for several decades, but have met with limited success. Although …

Targeted drug delivery to endothelial cells lining the vascular lumen will provide effective,
precise andsafe therapeutic interventions for treatment of diverse disease conditions …

Endothelium, a thin monolayer of specialized cells lining the lumen of blood vessels is the
key regulatory interface between blood and tissues. Endothelial abnormalities are …

Most clinically approved drugs (primarily small molecules or antibodies) are rapidly cleared
from circulation and distribute throughout the body. As a consequence, only a small portion …

Significant challenges remain in targeting drugs to diseased vasculature; most important
being rapid blood flow with high shear, limited availability of stable targets, and …

Vascular‐targeted nanocarriers are an attractive option for the treatment of a number of
cardiovascular diseases, as they allow for more specific delivery and increased efficacy of …