Stroke induces a plastic state in the brain. This period of enhanced plasticity leads to the
sprouting of new axons, the formation of new synapses and the remapping of sensory-motor …

Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which
results in damage to neuronal networks and the impairment of sensation, movement or …

Stroke is the leading cause of complex adult disability in the world. Recovery from stroke is
often incomplete, which leaves many people dependent on others for their care. The …

Stroke is among the most common causes of adult disability worldwide, and its disease
burden is shifting towards that of a long-term condition. Therefore, the development of …

With increasing rates of survival throughout the past several years, stroke remains one of the
leading causes of adult disability. Following the onset of stroke, spontaneous mechanisms of …

A wide range of therapies shows promise for improving poststroke brain repair. Insights into
the neurobiology of brain repair after stroke in animals and in humans continue to accrue …

Ischemic stroke is a devastating brain injury and an important cause of neurologic disability
worldwide and across the lifespan. Despite the physical, social, and economic burdens of …

Stroke disturbs both the structural and functional integrity of the brain. The understanding of
stroke pathophysiology has improved greatly in the past several decades. However …

Among the therapeutic strategies under study to improve long-term outcome after stroke are
drugs targeting events that underlie recovery. Drugs that enhance recovery are separate …

Changes in brain circuits occur within specific paradigms of action in the adult brain. These
paradigms include changes in behavioral activity patterns, alterations in environmental …