Why are people with focal epilepsy not continuously having seizures? Previous neuronal
signalling work has implicated gamma-aminobutyric acid balance as integral to seizure …

Normal brain functioning is presumed to depend upon interacting regions within large-scale
neuronal networks. Increasing evidence exists that interictal network alterations in focal …

Patients with drug-resistant focal epilepsy are often candidates for invasive surgical
therapies. In these patients, it is necessary to accurately localize seizure generators to …

Epilepsy is among the most common brain network disorders, and it is associated with
substantial morbidity and increased mortality. Although focal epilepsy was traditionally …

Objective In patients with medically refractory focal epilepsy, stereotactic‐
electroencephalography (SEEG) can aid in localizing epileptogenic regions for surgical …

Epilepsy–the world's most common serious brain disorder–is defined by recurrent
unprovoked seizures that result from complex interactions between distributed neural …

Background Although focal epilepsies are increasingly recognized to affect multiple and
remote neural systems, the underlying spatiotemporal pattern and the relationships between …

The neurophysiological patterns that correlate with partial (focal) seizures are well defined in
humans by standard electroencephalogram (EEG) and presurgical depth electrode …

Patients with medically-refractory focal epilepsy may be candidates for neurosurgery and
some may require placement of intracranial EEG electrodes to localise seizure onset …

Purpose: The current gold standard for the localization of the cortical regions responsible for
the initiation and propagation of the ictal activity is through the use of invasive …