In addition to fatty acids, glucose and lactate are important myocardial substrates under
physiologic and stress conditions. They are metabolized to pyruvate, which enters …

The myocardium is metabolically flexible; however, impaired flexibility is associated with
cardiac dysfunction in conditions including diabetes and heart failure. The mitochondrial …

Cardiomyocytes rely on metabolic substrates, not only to fuel cardiac output, but also for
growth and remodelling during stress. Here we show that mitochondrial pyruvate carrier …

The metabolic rewiring of cardiomyocytes is a widely accepted hallmark of heart failure (HF).
These metabolic changes include a decrease in mitochondrial pyruvate oxidation and an …

Gluconeogenesis is critical for maintenance of euglycemia during fasting. Elevated
gluconeogenesis during type 2 diabetes (T2D) contributes to chronic hyperglycemia …

The neonatal mammalian heart is capable of regeneration for a brief window of time after
birth. However, this regenerative capacity is lost within the first week of life, which coincides …

Pyruvate constitutes a critical branch point in cellular carbon metabolism. We have identified
two proteins, Mpc1 and Mpc2, as essential for mitochondrial pyruvate transport in yeast …

Carrier-facilitated pyruvate transport across the inner mitochondrial membrane plays an
essential role in anabolic and catabolic intermediary metabolism. Mitochondrial pyruvate …

Mitochondrial import of pyruvate by the mitochondrial pyruvate carrier (MPC) is a central
step which links cytosolic and mitochondrial intermediary metabolism. To investigate the role …

Mitochondria generate ATP and building blocks for cell growth and regeneration, using
pyruvate as the main substrate. Here we introduce PyronicSF, a user-friendly GFP-based …