Incorporating biological and clinical insights into variant choice for Mendelian randomisation: examples and principles
Mendelian randomisation is an accessible and valuable epidemiological approach to
provide insight into the causal nature of relationships between risk factor exposures and …
provide insight into the causal nature of relationships between risk factor exposures and …
Mendelian randomization in hepatology: A review of principles, opportunities, and challenges
Mendelian Randomization has become a popular tool to assess causal relationships using
existing observational data. While randomized controlled trials are considered the gold …
existing observational data. While randomized controlled trials are considered the gold …
First release of Mendelian randomisation book in Chinese
The original English book, authored by Dr Stephen Burgess and Professor Simon G
Thompson from the University of Cambridge, was first published by Chapman and Hall in …
Thompson from the University of Cambridge, was first published by Chapman and Hall in …
Mendelian randomization in the era of genomewide association studies
PMA Sleiman, SFA Grant - Clinical chemistry, 2010 - academic.oup.com
Background: Observational epidemiology has been instrumental in identifying modifiable
causes of common diseases, and, in turn, substantially impacting public health. Spurious …
causes of common diseases, and, in turn, substantially impacting public health. Spurious …
Mendelian randomization: where are we now and where are we going?
S Burgess, NJ Timpson, S Ebrahim… - International journal …, 2015 - academic.oup.com
The methodology and application of Mendelian randomization to study causal mechanisms
in health and disease has developed dramatically over the past decade. New methods …
in health and disease has developed dramatically over the past decade. New methods …
Randomised by (your) god: robust inference from an observational study design
GD Smith - Journal of Epidemiology & Community Health, 2006 - jech.bmj.com
He was sceptical of the diagnosis at the time, but evidently thought little more about it. 1
Eleven years later he was informed that his sister, Helen (fig 1), was acutely ill in a …
Eleven years later he was informed that his sister, Helen (fig 1), was acutely ill in a …
Commentary: Can 'many weak'instruments ever be 'strong'?
NA Sheehan, V Didelez - International journal of epidemiology, 2011 - academic.oup.com
Investigations into the aetiology of common complex diseases based on observational data
should make use of any opportunity to reduce bias due to unobserved confounding. In this …
should make use of any opportunity to reduce bias due to unobserved confounding. In this …
Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors
Finding individual-level data for adequately-powered Mendelian randomization analyses
may be problematic. As publicly-available summarized data on genetic associations with …
may be problematic. As publicly-available summarized data on genetic associations with …
Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
Mendelian randomization: new applications in the coming age of hypothesis-free causality
DM Evans, G Davey Smith - Annual review of genomics and …, 2015 - annualreviews.org
Mendelian randomization (MR) is an approach that uses genetic variants associated with a
modifiable exposure or biological intermediate to estimate the causal relationship between …
modifiable exposure or biological intermediate to estimate the causal relationship between …