Mammalian cells possess a multifaceted antioxidant enzyme system, which includes
superoxide dismutases, catalase, the peroxiredoxin/thioredoxin and the glutathione …

Simple Summary Glutathione peroxidase 1 (GPX1), as one of the most important antioxidant
enzymes, maintains cellular redox balance by regulating reactive oxygen species levels. In …

Glutathione peroxidases are well known antioxidant enzymes. They catalyze the reduction
of hydrogen peroxide or organic hydroperoxides using glutathione. Among the reported 8 …

The glutathione peroxidases, a family of selenocysteine-containing redox enzymes, play
pivotal roles in balancing the signaling, immunomodulatory, and deleterious effects of …

Cancer cells produce high amounts of reactive oxygen species (ROS) and evade apoptosis.
Hydroperoxides support proliferation, invasion, migration and angiogenesis, but at higher …

Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

Glutathione peroxidase 3 (GPx3), a major scavenger of reactive oxygen species (ROS) in
plasma, acts as a redox signal modulator. However, the mechanism underlying GPx3 …

Abstract Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is
found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it …

Oxidative stress is a disturbance in the equilibrium among free radicals, reactive oxygen
species, and endogenous antioxidant defense mechanisms. Oxidative stress is a result of …

Abstract Glutathione peroxidase-1 (GPX1) represents the first identified mammalian
selenoprotein, and our understanding in the metabolic regulation and function of this …