Leptin regulates lipid metabolism, maximizing insulin sensitivity; however, peripheral leptin
resistance is not fully understood, and its contribution to metabolic dysfunction-associated …

Background Leptin is an adipocyte-derived hormone that plays a crucial role in energy
homeostasis and lipid metabolism. Most of the biological effects of leptin are exerted through …

Background Leptin resistance occurs in obese patients, but its independent contribution to
adiposity and the accompanying metabolic diseases, ie, diabetes, liver steatosis, and …

Since non-alchoholic steatohepatitis (NASH) is often accompanied with metabolic syndrome
comprising obesity, type-2 diabetes and hypertension, it is hypothesized that …

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis are components
of the metabolic syndrome. Serum leptin levels are elevated in obesity, but the role of leptin …

AIM: To determine the role of leptin system in non-alcoholic fatty liver disease (NAFLD)
development by delineating the changes in serum levels of leptin and soluble leptin receptor …

The adipocyte hormone, leptin has been demonstrated to have profibrogenic actions in vitro
and in animal models. However, no correlation was found between plasma leptin levels and …

According to the latest WHO data, in the world there are 2 billion adults and 381 million
children and adolescents from 0 to 19 years old, who are overweight or obese. This is due to …

Abstract Background and Aim Genetic polymorphism has been implicated as a factor for the
occurrence of non‐alcoholic fatty liver disease (NAFLD). This study attempted to assess …

Since its discovery twenty-five years ago, the fat-derived hormone leptin has provided a
revolutionary framework for studying the physiological role of adipose tissue as an …