SGLTs are sodium glucose transporters found on the luminal membrane of the proximal
tubule, where they reabsorb some 180 g (1 mol) of glucose from the glomerular filtrate each …

The kidney has a pivotal role in maintaining glucose homeostasis by using glucose as a
metabolic fuel, by producing glucose through gluconeogenesis, and by reabsorbing all …

The kidneys in normoglycemic humans filter 160–180 g of glucose per day (∼ 30% of daily
calorie intake), which is reabsorbed and returned to the systemic circulation by the proximal …

Glucose is freely filtered in the glomeruli before being almost entirely reabsorbed into
circulation from the proximal renal tubules. The sodium–glucose cotransporter 2 (SGLT2) …

Glucose in the glomerular ultrafiltrate is actively reabsorbed by sodium glucose transporters
(SGLT) in the proximal tubule. The SGLT2 protein is a high capacity molecule responsible …

Background: The kidney plays a central role in the regulation of plasma glucose levels,
although until recently this has not been widely appreciated or considered a target for …

Inhibition of the sodium–glucose cotransporter (SGLT) 2 in the proximal tubule of the kidney
has a broad range of effects on renal function and plasma volume homeostasis, as well as …

The physiological and pathological handling of glucose via sodium–glucose cotransporter-2
(SGLT2) in the kidneys has been evolving, and SGLT2 inhibitors have been focused upon …

Inhibiting sodium–glucose co-transporters (SGLTs), which have a key role in the
reabsorption of glucose in the kidney, has been proposed as a novel therapeutic strategy for …

Sodium glucose cotransporter 2 (SGLT2) inhibition is a novel and promising treatment for
diabetes under late-stage clinical development. It generally is accepted that SGLT2 …