Spinal cord injury and bladder dysfunction: new ideas about an old problem

CD Cruz, F Cruz - The scientific world journal, 2011 - Wiley Online Library
Control of the lower urinary tract (LUT) requires complex neuronal circuits that involve
elements located at the peripheral nervous system and at different levels of the central …

[HTML][HTML] Current knowledge and novel frontiers in lower urinary tract dysfunction after spinal cord injury: Basic research perspectives

N Wada, S Karnup, K Kadekawa, N Shimizu… - Urological …, 2022 - journals.lww.com
This review article aims to summarize the recent advancement in basic research on lower
urinary tract dysfunction (LUTD) following spinal cord injury (SCI) above the sacral level. We …

Impairment of sensory afferents by intrathecal administration of botulinum toxin A improves neurogenic detrusor overactivity in chronic spinal cord injured rats

A Coelho, R Oliveira, F Cruz, CD Cruz - Experimental Neurology, 2016 - Elsevier
Spinal cord injury (SCI) often leads to neurogenic detrusor overactivity (NDO) due to
sprouting of sensory afferents on the lumbosacral spinal cord. NDO is characterized by high …

Neurogenic detrusor overactivity in patients with spinal cord injury: evaluation and management

A Sahai, E Cortes, J Seth, MS Khan, J Panicker… - Current urology …, 2011 - Springer
Lower urinary tract dysfunction can have a significant impact on patients with spinal cord
injury. Over the years, many treatment options have become available. This article reviews …

[HTML][HTML] Molecular mechanisms of neurogenic lower urinary tract dysfunction after spinal cord injury

N Shimizu, T Saito, N Wada, M Hashimoto… - International journal of …, 2023 - mdpi.com
This article provides a synopsis of current progress made in fundamental studies of lower
urinary tract dysfunction (LUTD) after spinal cord injury (SCI) above the sacral level. Animal …

[HTML][HTML] Assessing neurogenic lower urinary tract dysfunction after spinal cord injury: Animal models in preclinical neuro-urology research

AW Doelman, F Streijger, SJA Majerus, MS Damaser… - Biomedicines, 2023 - mdpi.com
Neurogenic bladder dysfunction is a condition that affects both bladder storage and voiding
function and remains one of the leading causes of morbidity after spinal cord injury (SCI) …

Pharmacologic and potential biologic interventions to restore bladder function after spinal cord injury

N Yoshimura, CP Smith, MB Chancellor… - Current opinion in …, 2000 - journals.lww.com
Spinal cord injury disrupts voluntary control of voiding and the normal reflex pathways that
coordinate bladder and urethral sphincter function. The present review addresses studies in …

Effects of intravesical onabotulinumtoxinA on bladder dysfunction and autonomic dysreflexia after spinal cord injury: role of nerve growth factor

MS Elkelini, DJ Bagli, M Fehlings… - BJU …, 2012 - Wiley Online Library
Study Type–Aetiology (case control) Level of Evidence 3c What's known on the subject? and
What does the study add? Neurogenic detrusor overactivity (NDO) and autonomic …

[HTML][HTML] Neurogenic bladder physiology, pathogenesis, and management after spinal cord injury

NE Perez, NP Godbole, K Amin, R Syan… - Journal of personalized …, 2022 - mdpi.com
Urinary incontinence is common after spinal cord injury (SCI) due to loss of supraspinal
coordination and unabated reflexes in both autonomic and somatic nervous systems; if …

Disordered control of the urinary bladder after human spinal cord injury: what are the problems?

PJ Potter - Progress in brain research, 2006 - Elsevier
Spinal cord injury has a profound impact on the storage and voiding functions of the urinary
bladder. Loss of autonomic and somatic control mechanisms leads to hypo-or hyperactivity …